细胞外囊泡作为治疗诊断手段的未来——一份国际细胞外囊泡学会（ISEV）会议报告
The future of Extracellular Vesicles as Theranostics - an ISEV meeting report.
作者信息
Soekmadji Carolina, Li Bo, Huang Yiyao, Wang Haifang, An Taixue, Liu Chunchen, Pan Weilun, Chen Jing, Cheung Lesley, Falcon-Perez Juan Manuel, Gho Yong Song, Holthofer Harry B, Le Minh T N, Marcilla Antonio, O'Driscoll Lorraine, Shekari Faezeh, Shen Tang Long, Torrecilhas Ana Claudia, Yan Xiaomei, Yang Fuquan, Yin Hang, Xiao Yu, Zhao Zezhou, Zou Xue, Wang Qian, Zheng Lei
机构信息
Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
出版信息
J Extracell Vesicles. 2020 Sep 4;9(1):1809766. doi: 10.1080/20013078.2020.1809766.
Abstract
The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on "EVs in Clinical Theranostic". Here, we report the conclusions of roundtable discussions on the current advancement in the analysis technologies and we provide some guidelines to researchers in the field to consider the use of EVs in clinical application. The main challenges and the requirements for EV separation and characterization strategies, quality control and clinical investigation were discussed to promote the application of EVs in future clinical studies.
摘要
在过去十年中，细胞外囊泡（EVs）在临床诊疗中的应用发展迅速。2018年11月，国际细胞外囊泡协会（ISEV）举办了一次关于“临床诊疗中的EVs”的研讨会。在此，我们报告关于分析技术当前进展的圆桌讨论结论，并为该领域的研究人员提供一些指导方针，以考虑在临床应用中使用EVs。讨论了EV分离和表征策略、质量控制及临床研究的主要挑战和要求，以促进EVs在未来临床研究中的应用。
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