Hu Guoku, Witwer Kenneth W, Bond Vincent C, Haughey Norman, Kashanchi Fatah, Pulliam Lynn, Buch Shilpa
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Extracell Vesicles. 2017 Mar 10;6(1):1294360. doi: 10.1080/20013078.2017.1294360. eCollection 2017.
Extracellular vesicles (EVs) are globular, membrane bound nanovesicles (30-100 nm range) that are shed both during normal cellular functioning and under pathological conditions by most cell types. In recent years, there has been significant interest in the study of these vesicles as conduits for the delivery of information between cells from both analogous and disparate tissues. Their ability to carry specialised cargo including signalling mediators, proteins, messenger RNA and miRNAs characterises these vesicles as primary facilitators of cell-to-cell communication and regulation. EVs have also been demonstrated to play important roles in the field of cancer biology and metastasis. However, significant knowledge gaps exist in the role these vesicles play in the context of HIV infection and drug abuse. To foster discussion in this area a satellite symposium on "HIV, NeuroAIDS, Drug Abuse & EVs", was held in conjunction with the annual meeting of the International Society for Extracellular Vesicles (ISEV) in Bethesda, in April 2015. Experts in HIV and drug abuse fields were invited to share their findings on the role of EVs in HIV-1 infection and drug addiction. Additional discussion included current areas of research in EV biology in HIV infection and drug abuse.
细胞外囊泡（EVs）是球形的、有膜包裹的纳米囊泡（直径范围为30 - 100纳米），在大多数细胞类型的正常细胞功能过程以及病理条件下都会释放。近年来，人们对这些囊泡作为来自相似和不同组织的细胞间信息传递管道的研究产生了浓厚兴趣。它们携带包括信号介质、蛋白质、信使核糖核酸和微小核糖核酸等特定货物的能力，使这些囊泡成为细胞间通讯和调节的主要促进者。细胞外囊泡在癌症生物学和转移领域也被证明发挥着重要作用。然而，在这些囊泡在HIV感染和药物滥用背景下所起的作用方面，仍存在重大知识空白。为促进该领域的讨论，2015年4月在贝塞斯达与国际细胞外囊泡协会（ISEV）年会联合举办了一次关于“HIV、神经艾滋病、药物滥用与细胞外囊泡”的卫星研讨会。邀请了HIV和药物滥用领域的专家分享他们关于细胞外囊泡在HIV - 1感染和药物成瘾中作用的研究结果。其他讨论内容包括目前在HIV感染和药物滥用中细胞外囊泡生物学的研究领域。
