Saunier Valentin, Flahaut Emmanuel, Blatché Marie-Charline, Bergaud Christian, Maziz Ali
LAAS-CNRS, 7 Avenue du Colonel Roche, F-31031 Toulouse, France.
CIRIMAT, Université de Toulouse, CNRS, F-31062 Toulouse, France.
MethodsX. 2020 Oct 17;7:101106. doi: 10.1016/j.mex.2020.101106. eCollection 2020.
This present method describes a versatile approach for the electrochemical synthesis of a composite material of Poly (3,4-ethylenedioxythiophene) (PEDOT) and Carbon Nanofibers (CNFs) for neural interfaces and biosensing applications. Oxidized CNFs were utilized as dopants of PEDOT to prepare the composite coating through electrochemical deposition on microelectrodes arrays (MEA). The experimental results of this study showed that PEDOT:CNF microelectrodes exhibit remarkable electrochemical properties, combining low impedance, high surface area, high charge injection capability and reliable neurotransmitters monitoring using amperometric techniques. Taken together, these results suggest the great potential of PEDOT:CNF composite for developing next-generation multifunctional microelectrodes for applications in neural therapies.•A simple approach for the electrochemical synthesis of PEDOT:CNF composite material on microelectrodes for neural interfaces and neurochemical sensing.•PEDOT:CNF microelectrodes exhibit remarkable electrochemical properties, combining low impedance and high charge injection capabilities.•PEDOT:CNF microelectrodes allowed the reliable detection of neurotransmitters with improved sensitivity.
本方法描述了一种通用方法，用于电化学合成聚（3,4-乙撑二氧噻吩）（PEDOT）与碳纳米纤维（CNF）的复合材料，用于神经接口和生物传感应用。氧化的碳纳米纤维被用作PEDOT的掺杂剂，通过在微电极阵列（MEA）上进行电化学沉积来制备复合涂层。本研究的实验结果表明，PEDOT:CNF微电极具有显著的电化学性能，兼具低阻抗、高表面积、高电荷注入能力以及使用安培技术进行可靠的神经递质监测。综上所述，这些结果表明PEDOT:CNF复合材料在开发用于神经治疗的下一代多功能微电极方面具有巨大潜力。
• 一种在用于神经接口和神经化学传感的微电极上电化学合成PEDOT:CNF复合材料的简单方法。
• PEDOT:CNF微电极具有显著的电化学性能，兼具低阻抗和高电荷注入能力。
• PEDOT:CNF微电极能够可靠地检测神经递质，且灵敏度有所提高。
