Wang Kezhong, Frewin Christopher L, Esrafilzadeh Dorna, Yu Changchun, Wang Caiyun, Pancrazio Joseph J, Romero-Ortega Mario, Jalili Rouhollah, Wallace Gordon
Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, University of Wollongong, Wollongong, NSW, 2522, Australia.
Department of Bioengineering, University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX, 75080, USA.
Adv Mater. 2019 Apr;31(15):e1805867. doi: 10.1002/adma.201805867. Epub 2019 Feb 25.
Fabrication of flexible and free-standing graphene-fiber- (GF-) based microelectrode arrays with a thin platinum coating, acting as a current collector, results in a structure with low impedance, high surface area, and excellent electrochemical properties. This modification results in a strong synergistic effect between these two constituents leading to a robust and superior hybrid material with better performance than either graphene electrodes or Pt electrodes. The low impedance and porous structure of the GF results in an unrivalled charge injection capacity of 10.34 mC cm with the ability to record and detect neuronal activity. Furthermore, the thin Pt layer transfers the collected signals along the microelectrode efficiently. In vivo studies show that microelectrodes implanted in the rat cerebral cortex can detect neuronal activity with remarkably high signal-to-noise ratio (SNR) of 9.2 dB in an area as small as an individual neuron.
制备具有薄铂涂层的柔性独立石墨烯纤维（GF）基微电极阵列，该铂涂层用作集流体，可得到一种具有低阻抗、高表面积和优异电化学性能的结构。这种改性导致这两种成分之间产生强烈的协同效应，从而形成一种坚固且优异的混合材料，其性能优于石墨烯电极或铂电极。GF的低阻抗和多孔结构导致其具有无与伦比的10.34 mC cm的电荷注入能力，能够记录和检测神经元活动。此外，薄铂层可有效地沿微电极传输收集到的信号。体内研究表明，植入大鼠大脑皮层的微电极能够在小至单个神经元的区域内以高达9.2 dB的显著高信噪比（SNR）检测神经元活动。
