用于神经假体和神经接口应用的导电聚合物
Conducting Polymers for Neural Prosthetic and Neural Interface Applications.
作者信息
Green Rylie, Abidian Mohammad Reza
机构信息
Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, NSW, 2052, Australia.
Biomedical Engineering Department Materials Science & Engineering Department, Chemical Engineering Department Materials Research Institute and Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA.
出版信息
Adv Mater. 2015 Dec 9;27(46):7620-37. doi: 10.1002/adma.201501810. Epub 2015 Sep 28.
Abstract
Neural-interfacing devices are an artificial mechanism for restoring or supplementing the function of the nervous system, lost as a result of injury or disease. Conducting polymers (CPs) are gaining significant attention due to their capacity to meet the performance criteria of a number of neuronal therapies including recording and stimulating neural activity, the regeneration of neural tissue and the delivery of bioactive molecules for mediating device-tissue interactions. CPs form a flexible platform technology that enables the development of tailored materials for a range of neuronal diagnostic and treatment therapies. In this review, the application of CPs for neural prostheses and other neural interfacing devices is discussed, with a specific focus on neural recording, neural stimulation, neural regeneration, and therapeutic drug delivery.
摘要
神经接口设备是一种用于恢复或补充因损伤或疾病而丧失的神经系统功能的人工机制。导电聚合物（CPs）因其能够满足多种神经治疗的性能标准而备受关注，这些治疗包括记录和刺激神经活动、神经组织再生以及递送生物活性分子以介导设备与组织的相互作用。CPs形成了一种灵活的平台技术，能够开发用于一系列神经诊断和治疗的定制材料。在这篇综述中，讨论了CPs在神经假体和其他神经接口设备中的应用，特别关注神经记录、神经刺激、神经再生和治疗药物递送。
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