School of Chemistry, Faculty of Science, Monash University, Clayton, VIC 3800, Australia.
Chem Commun (Camb). 2020 Nov 12;56(90):13907-13917. doi: 10.1039/d0cc05880g.
Biomolecules are very attractive nanomaterial components, generally, due to their biocompatibility, biodegradability, abundance, renewability, and sustainability, as compared to other resources for nanoparticle-based delivery systems. Biomolecule-based nanoencapsulation and nanodelivery systems can be designed and engineered for antimicrobial cargos in order to surmount classical and current challenges, including the emergence of multi-drug resistant strains of microorganisms, the low effectiveness and limitations in the applicability of the present antimicrobials, and biofilm formation. This feature article highlights the recent applications and capabilities of biomacromolecule-based nanomaterials for the delivery and activity enhancement of antimicrobials, and disruption of biofilms. Unique properties of some nanomaterials, arising from specific biomacromolecules, were also emphasized. We expect that this review will be helpful to researchers in engineering new types of antimicrobial nanocarriers, hybrid particles and colloidal systems with tailored properties.
生物分子是非常有吸引力的纳米材料组成部分，通常由于其生物相容性、可生物降解性、丰富性、可再生性和可持续性，与其他基于纳米颗粒的递药系统的资源相比具有优势。基于生物分子的纳米封装和纳米递药系统可以针对抗菌载药进行设计和工程化，以克服包括多药耐药菌株的出现、现有抗菌药物的低效率和应用局限性以及生物膜形成在内的经典和当前挑战。本文重点介绍了基于生物大分子的纳米材料在递药和增强抗菌药物活性以及破坏生物膜方面的最新应用和能力。还强调了一些纳米材料由于特定生物大分子而具有的独特性质。我们期望本综述将有助于研究人员开发新型抗菌纳米载体、具有定制性质的混合颗粒和胶体系统。
