Wang Li-Sheng, Gupta Akash, Rotello Vincent M
Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
ACS Infect Dis. 2016 Jan 8;2(1):3-4. doi: 10.1021/acsinfecdis.5b00116. Epub 2015 Oct 21.
Treatment of biofilm-associated infections is challenging, requiring the development of new therapeutic strategies. In this viewpoint, we discuss the use of nanoparticle-based systems as active therapeutic agents and as vehicles to transport drugs to the site of infection. These applications require understanding of the surface interactions of nanoparticles with bacteria/biofilms, an aspect that we likewise summarize.
生物膜相关感染的治疗具有挑战性，需要开发新的治疗策略。在本文观点中，我们讨论了基于纳米颗粒的系统作为活性治疗剂以及作为将药物输送到感染部位的载体的应用。这些应用需要了解纳米颗粒与细菌/生物膜的表面相互作用，我们同样对这一方面进行了总结。
