雷公藤红素：二十年研究的反思与未来展望。
Triptolide: reflections on two decades of research and prospects for the future.
机构信息
The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Department of Pharmacology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Hunterian Building, Room 516, Baltimore, MD 21205, USA.
出版信息
Nat Prod Rep. 2021 Apr 28;38(4):843-860. doi: 10.1039/d0np00054j.
Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have been used as anti-inflammatory and immunosuppressive remedies for centuries. Although triptolide and its analogs exhibit potent bioactivities against various cancers, and inflammatory and autoimmune diseases, none of them has been approved to be used in the clinic. This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development of triptolide.
涵盖年限
2000 年至 2020 年。雷公藤红素是从雷公藤（Tripterygium wilfordii Hook F）中分离得到的一种生物活性二萜三环氧，雷公藤是一种传统中药，其提取物作为抗炎和免疫抑制剂已有数百年的历史。虽然雷公藤红素及其类似物对各种癌症、炎症和自身免疫性疾病具有很强的生物活性，但没有一种被批准用于临床。本综述重点介绍了过去 20 年来雷公藤红素在材料来源、分子机制、临床进展和新药设计策略方面的进展，并对雷公藤红素未来的发展方向进行了展望。
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