Unité d'Endocrinologie-Gynécologie Pédiatrique, Service de Pédiatrie, Hôpital Arnaud-de-Villeneuve, CHU Montpellier et Université Montpellier, Montpellier, France.
Centre de Référence Maladies Rares du Développement Génital, Constitutif Sud, Hôpital Lapeyronie, CHU Montpellier et Université Montpellier, Montpellier, France.
Hum Reprod. 2021 Jan 1;36(1):82-86. doi: 10.1093/humrep/deaa267.
To date, vaginal/cervical clear cell adenocarcinoma (CCAC) has not been reported in the granddaughters of women treated with diethylstilbestrol (DES) during pregnancy. We present an 8-year-old girl with a history of severe vaginal bleeding who was diagnosed with cervical CCAC. She underwent fertility-sparing surgery and radiotherapy. No sign of recurrence was detected throughout a 10-year follow-up. Her grandmother had received DES therapy during pregnancy with the patient's mother. Although no direct causal link is demonstrated, this case raises for the first time, the hypothesis of multigenerational effects of DES in girls and strongly suggests the need to follow the granddaughters of DES-treated women.
迄今为止，在接受己烯雌酚（DES）治疗的孕妇的孙女中尚未报道阴道/宫颈透明细胞腺癌（CCAC）。我们报告了一名 8 岁女孩的病例，她有严重阴道出血病史，被诊断为宫颈 CCAC。她接受了保留生育能力的手术和放疗。在 10 年的随访中未发现复发迹象。她的祖母在怀她母亲时接受了 DES 治疗。尽管没有直接的因果关系，但该病例首次提出了 DES 对女孩多代效应的假说，并强烈表明需要对 DES 治疗女性的孙女进行随访。
