Radius Health, Inc, Waltham, MA, USA.
University of Alabama at Birmingham, Birmingham, AL, USA.
Ann Pharmacother. 2021 Jul;55(7):821-829. doi: 10.1177/1060028020970518. Epub 2020 Nov 4.
Osteoporosis-related fractures are an important public health burden.
To examine health care costs in Medicare patients with an osteoporosis-related fracture.
Medicare fee-for-service members with an osteoporosis-related fracture between January 1, 2010, to September 30, 2014 were included. A nonfracture comparator group was selected by propensity score matching. Generalized linear models using a gamma distribution were used to compare costs between fracture and nonfracture cohorts.
A total of 885 676 Medicare beneficiaries had fracture(s) and met inclusion criteria. Average age was 80.5 (±8.4) years; 91% were White, and 94% female. Mean all-cause costs were greater in the fracture vs nonfracture cohort ($47 163.25 vs $16 034.61) overall and for men ($52 273.79 vs $17 352.68). The highest mean costs were for skilled nursing facility ($29 216), inpatient costs ($24 190.19), and hospice care ($20 996.83). The highest incremental costs versus the nonfracture cohort were for hip ($71 057.83 vs $16 807.74), spine ($37 543.87 vs $16 860.49), and radius/ulna ($24 505.27 vs $14 673.86). Total medical and pharmacy costs for patients who experienced a second fracture were higher compared with those who did not ($78 137.59 vs $44 467.47). Proportionally more patients in the fracture versus nonfracture cohort died (18% vs 9.3%), with higher death rates among men (20% vs 11%).
The current findings suggest a significant economic burden associated with fractures. Early identification and treatment of patients at high risk for fractures is of paramount importance for secondary prevention and reduced mortality.
骨质疏松性骨折是一个重要的公共健康负担。
研究骨质疏松性骨折患者的医疗保健费用。
纳入 2010 年 1 月 1 日至 2014 年 9 月 30 日期间患有骨质疏松性骨折的 Medicare 按服务项目付费患者。通过倾向评分匹配选择非骨折对照组。使用伽马分布的广义线性模型比较骨折组和非骨折组之间的成本。
共有 885676 名 Medicare 受益人发生骨折且符合纳入标准。平均年龄为 80.5(±8.4)岁;91%为白人,94%为女性。总体而言,骨折组的全因成本高于非骨折组($47163.25 比 $16034.61),男性的情况也是如此($52273.79 比 $17352.68)。最高的平均费用是在疗养院($29216)、住院费用($24190.19)和临终关怀($20996.83)。与非骨折组相比,髋部($71057.83 比 $16807.74)、脊柱($37543.87 比 $16860.49)和桡骨/尺骨($24505.27 比 $14673.86)骨折的增量成本最高。与未发生第二次骨折的患者相比,发生第二次骨折的患者的总医疗和药物费用更高($78137.59 比 $44467.47)。骨折组的死亡比例高于非骨折组(18%比 9.3%),男性的死亡率更高(20%比 11%)。
目前的研究结果表明,骨折与重大经济负担相关。早期识别和治疗高风险骨折患者对于二级预防和降低死亡率至关重要。