Department of Convergence Medicine, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 05505, South Korea.
ANYMEDI Inc, Seoul, 05505, South Korea.
Sci Rep. 2020 Nov 4;10(1):18976. doi: 10.1038/s41598-020-74110-z.
Interventional devices including intragastric balloons are widely used to treat obesity. This study aims to develop 3D-printed, patient-specific, and anthropomorphic gastric phantoms with mechanical properties similar to those of human stomach. Using computed tomography gastrography (CTG) images of three patients, gastric phantoms were modelled through shape registration to align the stomach shapes of three different phases. Shape accuracies of the original gastric models versus the 3D-printed phantoms were compared using landmark distances. The mechanical properties (elongation and tensile strength), number of silicone coatings (0, 2, and 8 times), and specimen hardness (50, 60, and 70 Shore A) of three materials (Agilus, Elastic, and Flexa) were evaluated. Registration accuracy was significantly lower between the arterial and portal phases (3.16 ± 0.80 mm) than that between the portal and delayed phases (8.92 ± 0.96 mm). The mean shape accuracy difference was less than 10 mm. The mean elongations and tensile strengths of the Agilus, Elastic, and Flexa were 264%, 145%, and 146% and 1.14, 1.59, and 2.15 MPa, respectively, and their mechanical properties differed significantly (all p < 0.05). Elongation and tensile strength assessments, CTG image registration and 3D printing resulted in highly realistic and patient-specific gastric phantoms with reasonable shape accuracies.
介入设备，包括胃内球囊，被广泛用于治疗肥胖症。本研究旨在开发具有类似人体胃机械性能的 3D 打印、个体化和拟人化的胃模型。使用三位患者的计算机断层扫描胃造影（CTG）图像，通过形状配准对胃模型进行建模，以对齐三个不同阶段的胃形状。使用标志点距离比较原始胃模型与 3D 打印模型的形状精度。评估了三种材料（Agilus、Elastic 和 Flexa）的机械性能（伸长率和拉伸强度）、硅酮涂层次数（0、2 和 8 次）和标本硬度（50、60 和 70 Shore A）。动脉期和门静脉期之间的配准精度显著低于门静脉期和延迟期之间的配准精度（3.16±0.80mm 比 8.92±0.96mm）。形状精度的平均差异小于 10mm。Agilus、Elastic 和 Flexa 的平均伸长率和拉伸强度分别为 264%、145%和 146%和 1.14、1.59 和 2.15MPa，它们的机械性能差异显著（均 p<0.05）。伸长率和拉伸强度评估、CTG 图像配准和 3D 打印产生了具有合理形状精度的高度逼真和个体化的胃模型。
