Division of Endocrinology and Metabolism, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta, 10430, Indonesia.
Metabolic, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Sci Rep. 2020 Nov 4;10(1):19023. doi: 10.1038/s41598-020-75781-4.
In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults. The levels of IGF-1 and IGFBP3 were measured in 1669 subjects aged ≥ 16 years, before and after receiving four rounds of albendazole 400 mg/day or matching placebo for three consecutive days. Helminth infection status was assessed by microscopy (Kato-Katz) and PCR. Serum free IGF-1 level was significantly lower in helminth-infected subjects [mean difference and 95% CI - 0.068 (- 0.103; - 0.033), P < 0.001 after adjustment for age, sex, body mass index, and fasting insulin level]. There was no difference in IGFBP-3 level between helminth infected versus non-infected subjects. In the whole study population, albendazole treatment significantly increased serum free IGF-1 level [estimate and 95% CI 0.031 (0.004; - 0.057), P = 0.024] whereas no effect was found on the IGFBP-3 level. Our study showed that helminth infection in adults is associated with lower free IGF-1 levels but not with IGFBP-3 and albendazole treatment significantly increases free IGF-1 levels in the study population.Clinical Trial Registration: https://www.isrctn.com/ISRCTN75636394 .
在儿童中，土壤传播性蠕虫感染与营养不良和生长迟缓有关，而生长迟缓与 IGF-1 水平降低有关。在成年人中，IGF-1 具有合成代谢和代谢功能，与营养状况有关。在这里，我们评估了蠕虫感染对成年人游离 IGF-1 及其主要结合蛋白 IGFBP-3 的影响。在接受 4 轮 400mg/天阿苯达唑或连续 3 天匹配安慰剂治疗之前和之后，测量了 1669 名年龄≥16 岁的受试者的 IGF-1 和 IGFBP3 水平。通过显微镜检查（加藤-卡茨）和 PCR 评估蠕虫感染状态。在感染蠕虫的受试者中，血清游离 IGF-1 水平明显降低[平均差异和 95%CI-0.068（-0.103；-0.033），P<0.001，调整年龄、性别、体重指数和空腹胰岛素水平后]。感染与非感染的受试者之间 IGFBP-3 水平无差异。在整个研究人群中，阿苯达唑治疗显著增加了血清游离 IGF-1 水平[估计值和 95%CI0.031（0.004；-0.057），P=0.024]，而对 IGFBP-3 水平没有影响。我们的研究表明，成年人的蠕虫感染与较低的游离 IGF-1 水平有关，但与 IGFBP-3 无关，阿苯达唑治疗显著增加了研究人群中的游离 IGF-1 水平。临床试验注册：https://www.isrctn.com/ISRCTN75636394。
