Van Heerden J J
S Afr Med J. 1977 Aug 27;52(10):396-9.
In a double-blind between-patient study of 69 patients with sports injuries of the knee, diclophenac sodium (Voltaren) was significantly superior to oxyphenbutazone (Tanderil) and placebo in improving the degree of swelling and the condition of the injured knee. Both drugs were superior to placebo with regard to analgesia by the second day of treatment. In addition, diclophenac sodium significantly improved the condition of the injured knee by the end of the trial. Three patients dropped out of the trial for reasons not related to the drug. Two patients in the diclophenac sodium group failed to complete the trial due to rapid recovery and 1 each in the diclophenac sodium and oxyphenbutazone groups because of poor tolerability. Nine patients who completed the trial reported mild to moderate side-effects, consisting mainly of drowsiness and nausea.
在一项针对69名膝关节运动损伤患者的双盲患者间研究中，双氯芬酸钠（扶他林）在改善肿胀程度和受伤膝关节状况方面明显优于羟基保泰松（坦度尔）和安慰剂。在治疗的第二天，两种药物在镇痛方面均优于安慰剂。此外，在试验结束时，双氯芬酸钠显著改善了受伤膝关节的状况。三名患者因与药物无关的原因退出试验。双氯芬酸钠组有两名患者因恢复迅速而未能完成试验，双氯芬酸钠组和羟基保泰松组各有一名患者因耐受性差而未能完成试验。九名完成试验的患者报告了轻度至中度的副作用，主要包括嗜睡和恶心。
