Qiu Yan, Ren Wen, Liu Ying, Chen Wei-Er, Pan Xiao-Hua, Ren Jing-Jing
Department of General Practice, the First Affiliated Hospital, Zhejiang University, # 97 Qingchun Road, Hangzhou 310003, China.
Department of General Practice, Bei Lun District People's Hospital, # 1288 Lushan Dong Road, Ningbo 315800, China.
EClinicalMedicine. 2020 Sep 20;27:100544. doi: 10.1016/j.eclinm.2020.100544. eCollection 2020 Oct.
A comprehensive evaluation of the burden of inflammation bowel disease (IBD) is important for identifying potential strategies to control the disease. We present results from the Global Burden of Diseases (GBD) 2017 of IBD at the national level, the trends in disease burden and its epidemiological features in China.
Using the methods and results from GBD 2017, we describe the IBD burden based on the prevalence, incidence, mortality, years of lost (YLLs), the years of life lived with disability (YLDs) and disability-adjusted life years (DALYs) in China estimated using DisMod-MR 2·1. We additionally evaluated the rate of DALYs at national locations in 2017.
From 1990 to 2017, the cases, deaths, YLLs, YLDs and DALYs for IBD in China were from 1,047,991 to 2,665,081, from 5701 to 5198, from 188,814 to 107,373, from 157,581 to 394,887, from 346,396 to 502,260, respectively. Increasing trends were observed in prevalence (APC: 2·9%), incidence (APC: 1·1%), DALYs (APC: 0·8%) and YLDs (APC:2·9%). There were decreasing trends in mortality (APC: -1·0%) and YLLs (APC: -2·7%). As to the age-standardized rates of DALYs, it observed a decreasing trend (APC: -0·78%). Similar trends were observed in men and women. The age-standardized APCs in incidence, mortality and rate of YLLs among women were higher than those among men. The age-standardized rate of DALYs was 27·51 per 100,000 in 2017.
Between 1990 and 2017, China experienced a decrease in the age-standardized DALYs, mortality rates and YLLs due to IBD, despite an increase in the age-standardized rate of prevalence, incidence and YLDs. China is still one of the low endemic areas.
This work had no supporting funding
对炎症性肠病（IBD）负担进行全面评估对于确定控制该疾病的潜在策略至关重要。我们展示了2017年全球疾病负担（GBD）研究中IBD在国家层面的结果、中国疾病负担趋势及其流行病学特征。
使用GBD 2017的方法和结果，我们根据患病率、发病率、死亡率、寿命损失年数（YLLs）、伤残调整生命年数（YLDs）和伤残调整生命年（DALYs）描述中国IBD的负担，这些数据是使用DisMod-MR 2·1估算得出的。我们还评估了2017年中国各地区的DALYs率。
1990年至2017年，中国IBD的病例数、死亡数、YLLs、YLDs和DALYs分别从1,047,991例至2,665,081例、从5701例至5198例、从188,814例至107,373例、从157,581例至394,887例、从346,396例至502,260例。患病率（年度百分比变化：2·9%）、发病率（年度百分比变化：1·1%）、DALYs（年度百分比变化：0·8%）和YLDs（年度百分比变化：2·9%）呈上升趋势。死亡率（年度百分比变化：-1·0%）和YLLs（年度百分比变化：-2·7%）呈下降趋势。关于年龄标准化的DALYs率，呈下降趋势（年度百分比变化：-0·78%）。男性和女性呈现相似趋势。女性发病率、死亡率和YLLs率的年龄标准化年度百分比变化高于男性。2017年年龄标准化的DALYs率为每10万人27·51例。
1990年至2017年期间，尽管中国IBD的年龄标准化患病率、发病率和YLDs率有所上升，但年龄标准化的DALYs、死亡率和YLLs有所下降。中国仍是低发病地区之一。
本研究无资助资金
