Cui Guanglin, Yuan Aping
Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Faculty of Health Science, Nord University, Bodø, Norway.
Front Med (Lausanne). 2018 Jun 19;5:183. doi: 10.3389/fmed.2018.00183. eCollection 2018.
Recent epidemiological data have revealed a dramatically rising prevalence and incidence of inflammatory bowel diseases (IBDs) in Mainland China, a rapidly growing industrialized region, over the last two decades. We performed a systematic review to investigate the changing trends in the incidence of IBD in Mainland China and summarized the recent findings in risk factors associated with Chinese IBD. Relevant references were obtained from an electronic database search via MEDLINE and EMBASE (for English literatures), the China Academic Journals Full-text Database (CJFD) and the China Science Periodical Database (CSPD) in Wanfang Data (for Chinese literatures). Total 1,584 abstracts in Chinese and 171 abstracts in English were collected. Eight full-text with epidemiological data, 25 with risk factor data in Chinese and 7 full-text with epidemiological data, 12 with risk factor data in English were finally identified and included for analysis. Data from included epidemiological studies has showed a striking increase in the incidence rate of IBD in Mainland China over time, and current incidence rates for IBD, UC, and CD were 1.80 (IBD), 1.33 (UC), and 0.46/1,000,000 (CD), though it varies among regions and ethnic minority populations. In addition, several risk factors including environmental factors, diet, intestinal infectious agents, hygiene, stress, and lifestyle have been reported to be associated with the increased incidence of Chinese IBD. This systematic review revealed an increased incidence of IBD in Mainland China. Although it is still lower than that in the Western world, however, China has a huge population; therefore, the total number of IBD patients might not be so little as previously thought and the disease burden of IBD in China is likely underestimated. Recent epidemiological data have revealed a dramatically rising prevalence and incidence of inflammatory bowel diseases (IBD) in Mainland China, a rapidly growing industrialized region, over the last two decades.This systematic review based on recent epidemiological data has revealed a striking increase in the incidence rate of IBD in Mainland China, though it varies among regions and ethnic minority populations.Several potential risk factors of IBD including environmental factors, diet, intestinal infectious agents, hygiene, stress, and lifestyle have been reported to be associated with the increased incidence of Chinese IBD.This systematic review on epidemiologic and risk factor studies has expanded understanding of the occurrence, distribution, geographic variance and risk factors of Chinese IBD and will provide clinicians important information in understanding current status of IBD in Mainland China.
最近的流行病学数据显示，在过去二十年中，中国大陆这个快速发展的工业化地区，炎症性肠病（IBD）的患病率和发病率急剧上升。我们进行了一项系统综述，以调查中国大陆IBD发病率的变化趋势，并总结了与中国IBD相关的危险因素的最新研究结果。通过MEDLINE和EMBASE（用于英文文献）、中国学术期刊全文数据库（CJFD）和万方数据中的中国科学期刊数据库（CSPD）（用于中文文献）进行电子数据库检索，获取相关参考文献。共收集到1584篇中文摘要和171篇英文摘要。最终确定并纳入8篇有流行病学数据的全文、25篇有危险因素数据的中文文献以及7篇有流行病学数据的全文、12篇有危险因素数据的英文文献进行分析。纳入的流行病学研究数据显示，中国大陆IBD的发病率随时间显著增加，目前IBD、溃疡性结肠炎（UC）和克罗恩病（CD）的发病率分别为1.80（IBD）、1.33（UC）和0.46/100万（CD），尽管不同地区和少数民族人群有所差异。此外，据报道，包括环境因素、饮食、肠道感染因子、卫生、压力和生活方式在内的几个危险因素与中国IBD发病率的增加有关。这项系统综述揭示了中国大陆IBD发病率的上升。虽然仍低于西方世界，但中国人口众多；因此，IBD患者总数可能并不像以前认为的那么少，中国IBD的疾病负担可能被低估了。最近的流行病学数据显示，在过去二十年中，中国大陆这个快速发展的工业化地区，炎症性肠病（IBD）的患病率和发病率急剧上升。这项基于最新流行病学数据的系统综述揭示了中国大陆IBD发病率的显著增加，尽管不同地区和少数民族人群有所差异。据报道，IBD的几个潜在危险因素包括环境因素、饮食、肠道感染因子、卫生、压力和生活方式与中国IBD发病率的增加有关。这项关于流行病学和危险因素研究的系统综述扩展了对中国IBD的发生、分布、地理差异和危险因素的认识，并将为临床医生了解中国大陆IBD的现状提供重要信息。
