Monteiro W O, Noshirvani H F, Marks I M, Lelliott P T
Institute of Psychiatry, De Crespigny Park, London.
Br J Psychiatry. 1987 Jul;151:107-12. doi: 10.1192/bjp.151.1.107.
Forty-six patients with obsessive-compulsive disorder undergoing a double-blind controlled study of clomipramine and placebo were interviewed to assess changes in sexual function. Of 33 patients with previously normal organism, nearly all of the 24 on clomipramine developed total or partial anorgasmia; none of the 9 on placebo did so. Anorgasmia persisted with minimal tolerance over the five months that clomipramine was taken. Men and women were equally affected. Sexual side-effects are easily missed without a structured interview, and can detract from the value of drug treatment.
对46名正在进行氯米帕明和安慰剂双盲对照研究的强迫症患者进行了访谈，以评估性功能的变化。在33名之前性功能正常的患者中，服用氯米帕明的24名患者中几乎所有人都出现了完全或部分性高潮缺失；服用安慰剂的9名患者中无人出现这种情况。在服用氯米帕明的五个月里，性高潮缺失一直存在，耐受性极低。男性和女性受到的影响相同。如果没有结构化访谈，性副作用很容易被忽视，并且会降低药物治疗的价值。
