Nano Fusion Technology Research Group, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Tokida 3-15-1, Ueda 386-8567, Nagano, Japan.
Department of Materials, University of Manchester, Manchester M13 9PL, United Kingdom.
Int J Biol Macromol. 2021 Jan 1;166:1009-1021. doi: 10.1016/j.ijbiomac.2020.10.257. Epub 2020 Nov 2.
Blumea balsamifera oil loaded cellulose acetate nanofiber mats were prepared by electrospinning. The inclusion of blumea oil increased the nanofiber diameter. FTIR spectra confirm the addition of blumea oil in the nanofiber mats. The XRD pattern suggests that the inclusion of blumea oil has caused a misalignment in the polymer chains of the cellulose acetate. Thus, a decrease in the tensile strength was observed for the blumea oil loaded nanofibers. The increase in fiber diameter causes a reduction in the porosity of the nanofiber mats. The blumea oil loaded nanofiber mats showed antibacterial efficacy against Escherichia coli and Staphylococcus aureus. The blumea oil showed antioxidant abilities against the DPPH solution. MVTR of the neat and blumea oil loaded nanofiber mats was in the range of 2450-1750 g/m/day, which is adequate for the transport of air and moisture from the wound surface. Blumea oil loaded mats showed good cell viability ~92% for NIH 3T3 cells in more extended periods of incubation. A biphasic release profile was obtained, and the release followed the first-order kinetics depending upon the highest value of the coefficient of correlation R 2 (88.6%).
负载白苞筋骨草油的醋酸纤维素纳米纤维垫通过静电纺丝制备而成。白苞筋骨草油的加入增加了纳米纤维的直径。FTIR 光谱证实了白苞筋骨草油在纳米纤维垫中的加入。XRD 图谱表明，白苞筋骨草油的加入导致了醋酸纤维素聚合物链的错位。因此，负载白苞筋骨草油的纳米纤维的拉伸强度下降。纤维直径的增加导致纳米纤维垫的孔隙率降低。负载白苞筋骨草油的纳米纤维垫对大肠杆菌和金黄色葡萄球菌表现出抗菌功效。白苞筋骨草油对 DPPH 溶液显示出抗氧化能力。纯纳米纤维垫和负载白苞筋骨草油的纳米纤维垫的 MVTR 在 2450-1750g/m/天之间，足以促进伤口表面的空气和水分传输。在更长的孵育时间内，负载白苞筋骨草油的垫子表现出良好的细胞活力~92%，对于 NIH 3T3 细胞。获得了两相释放曲线，并且释放遵循一级动力学，这取决于相关系数 R 2 的最高值（88.6%）。
