Department of Chemistry, University of Fort Hare, Alice, Eastern Cape, 5700, South Africa.
Curr Drug Deliv. 2024;21(9):1226-1240. doi: 10.2174/0115672018262616231001191356.
Wound healing and skin regeneration are major challenges in chronic wounds. Among the types of wound dressing products currently available in the market, each wound dressing material is designed for a specific wound type. Some of these products suffer from various shortcomings, such as poor antibacterial efficacy and mechanical performance, inability to provide a moist environment, poor permeability to oxygen and capability to induce cell migration and proliferation during the wound healing process. Hydrogels and nanofibers are widely reported wound dressings that have demonstrated promising capability to overcome these shortcomings. Cellulose acetate is a semisynthetic polymer that has attracted great attention in the fabrication of hydrogels and nanofibers. Loading bioactive agents such as antibiotics, essential oils, metallic nanoparticles, plant extracts, and honey into cellulose acetate-based nanofibers and hydrogels enhanced their biological effects, including antibacterial, antioxidant, and wound healing. This review reports cellulose acetate-based hydrogels and nanofibers loaded with bioactive agents for wound dressing and skin regeneration.
创伤愈合和皮肤再生是慢性创面面临的主要挑战。在目前市场上可获得的各种创面敷贴产品中，每种创面敷贴材料都针对特定的创面类型而设计。这些产品中的一些存在各种缺点，例如抗菌功效和机械性能差、无法提供湿润环境、对氧气的渗透性差以及在创面愈合过程中诱导细胞迁移和增殖的能力差。水凝胶和纳米纤维是广泛报道的创面敷贴材料，它们已被证明具有克服这些缺点的潜力。醋酸纤维素是一种半合成聚合物，在水凝胶和纳米纤维的制备中引起了广泛关注。将抗生素、精油、金属纳米粒子、植物提取物和蜂蜜等生物活性物质负载到醋酸纤维素基纳米纤维和水凝胶中，增强了它们的生物学效应，包括抗菌、抗氧化和创面愈合。本综述报告了载有生物活性物质的醋酸纤维素基水凝胶和纳米纤维在创面敷贴和皮肤再生中的应用。
