用于疫苗研究与开发的组学和生物信息学方法以鉴定新型抗原。
Omics and Bioinformatics Approaches to Identify Novel Antigens for Vaccine Investigation and Development.
作者信息
Leitão Jorge H, Rodríguez-Ortega Manuel J
机构信息
iBB-Institute for Bioengineering and Biosciences, and Bioengineering Department, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal.
Department of Biochemistry and Molecular Biology, University of Córdoba, Campus de Excelencia Internacional CeiA3, 14071 Córdoba, Spain.
出版信息
Vaccines (Basel). 2020 Nov 3;8(4):653. doi: 10.3390/vaccines8040653.
Despite the outstanding technological advances achieved in the last few decades, infectious diseases remain a major societal challenge. From the variolation carried out in ancient China during the 15th century to the more advanced RNA and DNA vaccines presently available, vaccines have been proven as highly effective therapeutic tools to combat various infectious diseases. Vaccine research and development is now empowered with recent advances in Omics sciences and the developments of powerful bioinformatics tools. This Special Issue has gathered a total of nine original papers, including seven research papers and two reviews, illustrating the use of Omics data and bioinformatics in the research, design and development of vaccines against pathogens and cancer. The integration of knowledge from Omics and Bioinformatics will certainly boost vaccine research and development, leading to novel therapeutic tools against new and old pathogens and cancer in the near future.
尽管在过去几十年中取得了卓越的技术进步，但传染病仍然是一项重大的社会挑战。从15世纪中国古代进行的人痘接种到目前可用的更先进的RNA和DNA疫苗，疫苗已被证明是对抗各种传染病的高效治疗工具。组学科学的最新进展和强大的生物信息学工具的发展，为疫苗研发提供了助力。本期特刊共收集了9篇原创论文，其中包括7篇研究论文和2篇综述，阐述了组学数据和生物信息学在针对病原体和癌症的疫苗研究、设计与开发中的应用。组学和生物信息学知识的整合必将推动疫苗研发，在不久的将来带来针对新老病原体及癌症的新型治疗工具。
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