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肿瘤相关巨噬细胞-M2型癌细胞复合体与肺腺癌形态结构异质性改变的观察

The Tumor-Associated Macrophage-M2-Cancer Cell Complex and the Observation of Heterogeneous Modification of the Morphological Structure of Lung Adenocarcinoma.

作者信息

Xiao Wei-Hua, Yao Li-Ping, Li Min, Wang Min, Wu Liang, Jiang Mao-Fen, Ma Hai-Fen, Li Jun-Qiang, Chen Guo-Rong

机构信息

Department of Pathology, Ningbo Beilun People's Hospital, Ningbo 315800, People's Republic of China.

Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People's Republic of China.

出版信息

Onco Targets Ther. 2020 Oct 30;13:11139-11149. doi: 10.2147/OTT.S267157. eCollection 2020.

DOI:10.2147/OTT.S267157
PMID:33154653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7608484/
Abstract

OBJECTIVE

The aim of this study was to investigate the effect of the tumor-associated macrophage-m2-cancer cell complex (TAM-M2-CC) on the heterostructural modification of lung adenocarcinoma.

METHODS

The expression of CD163+/CD68+ in macrophages in the microenvironment of 161 cases of lung adenocarcinoma was identified by dual immunohistochemistry, and the association between a TAM-M2-CC and its growth, as well as the histological changes in lung adenocarcinoma cells, was assessed.

RESULTS

The morphological change of lung adenocarcinoma was related to the number of m2 phenotypes of the macrophages in the microenvironment of lung adenocarcinoma. TAM-M2-CCs were involved in the process of cancer cell recognition, association, and reconstruction.

CONCLUSION

The microenvironment of lung adenocarcinoma can affect the phenotypic distinction of macrophages, and the polarization recruitment, zombification, and formation of a TAM-M2-CC, which can also affect the local differentiation of lung adenocarcinoma to a certain extent. The applicable pathogenesis needs to be verified and studied further.

摘要

目的

本研究旨在探讨肿瘤相关巨噬细胞-M2-癌细胞复合物（TAM-M2-CC）对肺腺癌异质结构修饰的影响。

方法

采用双重免疫组化法鉴定161例肺腺癌微环境中巨噬细胞CD163+/CD68+的表达，并评估TAM-M2-CC与其生长以及肺腺癌细胞组织学变化之间的关联。

结果

肺腺癌的形态学改变与肺腺癌微环境中巨噬细胞M2表型数量有关。TAM-M2-CC参与癌细胞的识别、关联和重建过程。

结论

肺腺癌微环境可影响巨噬细胞的表型分化，以及TAM-M2-CC的极化募集、僵尸化和形成，这在一定程度上也会影响肺腺癌的局部分化。其适用的发病机制有待进一步验证和研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/2ab30a23376f/OTT-13-11139-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/9b5ba7fb84a9/OTT-13-11139-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/ff9f7c09dc38/OTT-13-11139-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/d37bd8017f43/OTT-13-11139-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/2ab30a23376f/OTT-13-11139-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/9b5ba7fb84a9/OTT-13-11139-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/ff9f7c09dc38/OTT-13-11139-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/d37bd8017f43/OTT-13-11139-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dcc/7608484/2ab30a23376f/OTT-13-11139-g0004.jpg

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