Valmari P, Peltola H, Ruuskanen O, Korvenranta H
Department of Pediatrics, University of Oulu, Finland.
Eur J Pediatr. 1987 Sep;146(5):515-8. doi: 10.1007/BF00441607.
The relationship of symptoms and signs to age and the reasons for consulting a physician were analyzed in 110 cases of culture-proven childhood bacterial meningitis. H. influenzae caused 74, meningococci 28, pneumococci 6 and streptococci 2 of the cases. Apart from fever (present in 94%), the most common symptoms according to age were as follows: 1-5 months: irritability (85%), 6-11 months: impaired consciousness (79%), 12 months or more: vomiting (82%) and neck rigidity (78%). Absence of neck rigidity at diagnosis was associated with young age (less than 12 months, P less than 0.001) and, in older children, to a short duration of symptoms (P less than 0.01) but not to the degree of CSF pleocytosis. Symptoms of meningitis caused by H. influenzae differed from those of meningococcal meningitis. Meningitis should be suspected in irritable or lethargic febrile children despite absence of neck rigidity. Fever and vomiting were the most frequent reasons for consulting a physician (60% and 31%, respectively). Despite the frequency and alarming character of irritability, impaired consciousness and neck rigidity, their presence led infrequently to a consultation (6%, 22% and 3%, respectively). Parental ignorance of such symptoms or of their importance may cause treatment delay, despite readily available medical services.
对110例经培养证实的儿童细菌性脑膜炎病例分析了症状和体征与年龄的关系以及就医原因。其中74例由流感嗜血杆菌引起,28例由脑膜炎球菌引起,6例由肺炎球菌引起,2例由链球菌引起。除发热(94%出现)外,按年龄划分最常见的症状如下:1至5个月:易激惹(85%),6至11个月:意识障碍(79%),12个月及以上:呕吐(82%)和颈部强直(78%)。诊断时无颈部强直与年龄小(小于12个月,P<0.001)有关,在年龄较大儿童中与症状持续时间短有关(P<0.01),但与脑脊液细胞增多程度无关。流感嗜血杆菌引起的脑膜炎症状与脑膜炎球菌性脑膜炎不同。即使没有颈部强直,对烦躁或嗜睡的发热儿童也应怀疑患有脑膜炎。发热和呕吐是就医最常见的原因(分别为60%和31%)。尽管易激惹、意识障碍和颈部强直很常见且令人担忧,但它们导致就医的情况很少(分别为6%、22%和3%)。尽管医疗服务便捷,但父母对这些症状或其重要性的忽视可能导致治疗延误。