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鼓足干劲：利用肠道类器官模型研究病毒感染。

Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection.

机构信息

OrganoVIR Lab, Department of Medical Microbiology, Amsterdam UMC, Academic Medical Center, University of Amsterdam, 1100 AZ Amsterdam, The Netherlands.

Department of Pediatrics Infectious Diseases, Emma Children's Hospital, Amsterdam UMC, Academic Medical Center, University of Amsterdam, 1100 AZ Amsterdam, The Netherlands.

出版信息

Viruses. 2020 Nov 11;12(11):1288. doi: 10.3390/v12111288.

DOI:10.3390/v12111288
PMID:33187072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7697248/
Abstract

The knowledge about enteric viral infection has vastly increased over the last eight years due to the development of intestinal organoids and enteroids that suppose a step forward from conventional studies using cell lines. Intestinal organoids and enteroids are three-dimensional (3D) models that closely mimic intestinal cellular heterogeneity and organization. The barrier function within these models has been adapted to facilitate viral studies. In this review, several adaptations (such as organoid-derived two-dimensional (2D) monolayers) and original intestinal 3D models are discussed. The specific advantages and applications, as well as improvements of each model are analyzed and an insight into the possible path for the field is given.

摘要

由于肠类器官和肠原代细胞的发展，人们对肠病毒感染的认识在过去八年中大大提高，这比使用细胞系的传统研究前进了一步。肠类器官和肠原代细胞是三维（3D）模型，它们非常接近地模拟了肠道细胞的异质性和组织。这些模型中的屏障功能已经过调整，以方便进行病毒研究。在这篇综述中，讨论了几种适应（例如类器官衍生的二维（2D）单层）和原始的肠道 3D 模型。分析了每种模型的具体优势和应用以及改进，并对该领域的可能发展方向进行了探讨。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594f/7697248/cded0d6f596f/viruses-12-01288-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594f/7697248/fe3425144d3b/viruses-12-01288-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594f/7697248/cded0d6f596f/viruses-12-01288-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594f/7697248/fe3425144d3b/viruses-12-01288-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594f/7697248/cded0d6f596f/viruses-12-01288-g002.jpg

相似文献

[1]
Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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本文引用的文献

[1]
Human Microphysiological Models of Intestinal Tissue and Gut Microbiome.

Front Bioeng Biotechnol. 2020-7-31

[2]
A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine.

Front Cell Infect Microbiol. 2020

[3]
Gut-on-a-chip: Current progress and future opportunities.

Biomaterials. 2020-10

[4]
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.

Cell Rep. 2020-6-19

[5]
Infection of bat and human intestinal organoids by SARS-CoV-2.

Nat Med. 2020-5-13

[6]
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.

Sci Immunol. 2020-5-13

[7]
SARS-CoV-2 productively infects human gut enterocytes.

Science. 2020-5-1

[8]
Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells.

Gastroenterology. 2020-7

[9]
Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses.

mBio. 2020-3-17

[10]
Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids.

Proc Natl Acad Sci U S A. 2020-1-2

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