来自Pf195的血清可保护夜猴，抑制恶性疟原虫在体外的生长。 - Suppr

Serum from Pf195 protected Aotus monkeys inhibit Plasmodium falciparum growth in vitro.

作者信息

Hui G S, Siddiqui W A

机构信息

Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, Leahi Hospital, University of Hawaii, Honolulu 96816.

出版信息

Exp Parasitol. 1987 Dec;64(3):519-22. doi: 10.1016/0014-4894(87)90068-3.

DOI:10.1016/0014-4894(87)90068-3

PMID:3315738

Abstract

摘要

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Serum from Pf195 protected Aotus monkeys inhibit Plasmodium falciparum growth in vitro.来自Pf195的血清可保护夜猴，抑制恶性疟原虫在体外的生长。

Exp Parasitol. 1987 Dec;64(3):519-22. doi: 10.1016/0014-4894(87)90068-3.

An effective immunization of Aotus trivirgatus monkeys against Plasmodium falciparum: a research note.对三带犰狳猴进行针对恶性疟原虫的有效免疫：一项研究笔记。

Bull World Health Organ. 1977;55(2-3):403.

Immunization of Aotus trivirgatus against Plasmodium falciparum with irradiated blood forms.用经辐照的血液形态对三带夜猴进行恶性疟原虫免疫接种。

Bull World Health Organ. 1979;57 Suppl 1(Suppl):153-7.

Antibody mediated strain-specific agglutination of Plasmodium falciparum--parasitized erythrocytes visualized by ethidium bromide staining.

Parasite Immunol. 1985 Nov;7(6):659-63. doi: 10.1111/j.1365-3024.1985.tb00109.x.

Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria.裂殖子表面被膜前体蛋白可使夜猴完全抵御恶性疟原虫疟疾。

Proc Natl Acad Sci U S A. 1987 May;84(9):3014-8. doi: 10.1073/pnas.84.9.3014.

Protection of Aotus monkeys after immunization with recombinant antigens of Plasmodium falciparum.用恶性疟原虫重组抗原免疫后对夜猴的保护作用。

Mem Inst Oswaldo Cruz. 1992;87 Suppl 3:413-22. doi: 10.1590/s0074-02761992000700070.

Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: further studies using SERA 1 and MF75.2 adjuvant.恶性疟原虫重组SERA蛋白在夜猴中诱导的保护性免疫：使用SERA 1和MF75.2佐剂的进一步研究

Infect Immun. 1993 May;61(5):2048-52. doi: 10.1128/iai.61.5.2048-2052.1993.

Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: adjuvant effects on induction of protective immunity.恶性疟原虫重组SERA蛋白在夜猴中诱导的保护性免疫：对保护性免疫诱导的佐剂效应

Infect Immun. 1993 May;61(5):2041-7. doi: 10.1128/iai.61.5.2041-2047.1993.

Immunization of experimental monkeys against Plasmodium falciparum: use of synthetic adjuvants.用合成佐剂对实验猴进行恶性疟原虫免疫接种

Bull World Health Organ. 1979;57 Suppl 1(Suppl):199-203.

Partial protection of Plasmodium falciparum-vaccinated Aotus trivirgatus against a challenge of a heterologous strain.恶性疟原虫疫苗接种的三带犰狳对异源菌株攻击的部分保护作用。

Am J Trop Med Hyg. 1978 Nov;27(6):1277-8. doi: 10.4269/ajtmh.1978.27.1277.

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Poly(I:C) adjuvant strongly enhances parasite-inhibitory antibodies and Th1 response against Plasmodium falciparum merozoite surface protein-1 (42-kDa fragment) in BALB/c mice.聚肌苷酸-聚胞苷酸佐剂可显著增强 BALB/c 小鼠对恶性疟原虫裂殖子表面蛋白-1（42kDa 片段）的抑制抗体和 Th1 应答。

Med Microbiol Immunol. 2018 Apr;207(2):151-166. doi: 10.1007/s00430-018-0535-4. Epub 2018 Feb 3.

Iron oxide nanoparticles as a clinically acceptable delivery platform for a recombinant blood-stage human malaria vaccine.氧化铁纳米颗粒作为一种临床可接受的重组血期人类疟疾疫苗传递平台。

FASEB J. 2013 Mar;27(3):1153-66. doi: 10.1096/fj.12-218362. Epub 2012 Nov 29.

T cell epitope regions of the P. falciparum MSP1-33 critically influence immune responses and in vitro efficacy of MSP1-42 vaccines.恶性疟原虫 MSP1-33 的 T 细胞表位区域对免疫反应和 MSP1-42 疫苗的体外疗效有重要影响。

PLoS One. 2011;6(9):e24782. doi: 10.1371/journal.pone.0024782. Epub 2011 Sep 13.

Total immunoglobulin G and IgG1 subclass levels specific for the MSP-1(19) of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodies.对于恶性疟原虫裂殖子表面蛋白1（19）[MSP-1(19)]具有特异性的总免疫球蛋白G及IgG1亚类水平，在具有加工抑制性抗体、阻断性抗体或中和性抗体的个体中有所不同。

Afr Health Sci. 2010 Jun;10(2):106-10.

In vitro growth-inhibitory activity and malaria risk in a cohort study in mali.在马里的一项队列研究中体外生长抑制活性和疟疾风险。

Infect Immun. 2010 Feb;78(2):737-45. doi: 10.1128/IAI.00960-09. Epub 2009 Nov 16.

Biological activities of anti-merozoite surface protein-1 antibodies induced by adjuvant-assisted immunizations in mice with different immune gene knockouts.在不同免疫基因敲除小鼠中，佐剂辅助免疫诱导产生的抗裂殖子表面蛋白-1抗体的生物学活性。

Clin Vaccine Immunol. 2008 Aug;15(8):1145-50. doi: 10.1128/CVI.00058-08. Epub 2008 Jun 18.

Adjuvant formulations possess differing efficacy in the potentiation of antibody and cell mediated responses to a human malaria vaccine under selective immune genes knockout environment.在选择性免疫基因敲除环境下，佐剂配方在增强对人类疟疾疫苗的抗体和细胞介导反应方面具有不同的功效。

Int Immunopharmacol. 2008 Jul;8(7):1012-22. doi: 10.1016/j.intimp.2008.03.005. Epub 2008 Apr 3.

The requirement of CD80, CD86, and ICAM-1 on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine.CD80、CD86和细胞间黏附分子-1对佐剂制剂增强针对恶性疟原虫血液期疫苗抗体反应能力的要求。

Vaccine. 2007 Dec 12;25(51):8549-56. doi: 10.1016/j.vaccine.2007.10.010. Epub 2007 Oct 26.

Plasmodium falciparum: immunization with MSP1-42 induced non-inhibitory antibodies that have no blocking activities but enhanced the potency of inhibitory anti-MSP1-42 antibodies.恶性疟原虫：用MSP1-42免疫诱导产生的非抑制性抗体没有阻断活性，但增强了抑制性抗MSP1-42抗体的效力。

Exp Parasitol. 2007 Apr;115(4):403-8. doi: 10.1016/j.exppara.2006.10.005. Epub 2006 Nov 21.

In vivo expression and immunological studies of the 42-kilodalton carboxyl-terminal processing fragment of Plasmodium falciparum merozoite surface protein 1 in the baculovirus-silkworm system.恶性疟原虫裂殖子表面蛋白1 42千道尔顿羧基末端加工片段在杆状病毒-家蚕系统中的体内表达及免疫学研究

Infect Immun. 2002 Jun;70(6):2772-9. doi: 10.1128/IAI.70.6.2772-2779.2002.

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Serum from Pf195 protected Aotus monkeys inhibit Plasmodium falciparum growth in vitro.

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