使用工程键盘进行交替手指敲击来测量帕金森病的僵硬程度的验证方法。
A validated measure of rigidity in Parkinson's disease using alternating finger tapping on an engineered keyboard.
机构信息
Stanford University School of Medicine, Department of Neurology and Neurological Sciences, Stanford, CA, USA; Vagelos College of Physicians and Surgeons, Columbia University, NY, USA.
Stanford University School of Medicine, Department of Neurology and Neurological Sciences, Stanford, CA, USA.
出版信息
Parkinsonism Relat Disord. 2020 Dec;81:161-164. doi: 10.1016/j.parkreldis.2020.10.047. Epub 2020 Nov 2.
INTRODUCTION
Reliable and accurate measures of rigidity have remained elusive in remote assessments of Parkinson's disease (PD). This has severely limited the utility of telemedicine in the care and treatment of people with PD. It has also had a large negative impact on the scope of available outcomes, and on the costs, of multicenter clinical trials in PD. The goal of this study was to determine if quantitative measures from an engineered keyboard were sensitive and related to clinical measures of rigidity.
METHODS
Sixteen participants with idiopathic PD, off antiparkinsonian medications, and eleven age-matched control participants performed a 30 second repetitive alternating finger tapping task on an engineered keyboard and were assessed with the Unified Parkinson's Disease Rating Scale - motor (UPDRS-III).
RESULTS
The speed of the key release was significantly slower in the PD compared to control cohorts (p < 0.0001). In the PD cohort key release speed correlated with the lateralized upper extremity UPDRS III rigidity score (r = - 0.58, p < 0.0001), but not with the lateralized upper extremity tremor score (r = - 0.14, p = 0.43).
CONCLUSIONS
This validated measure of rigidity complements our previous validation of temporal metrics of the repetitive alternating finger tapping task with the UPDRS III, bradykinesia and with the ability to quantify tremor, arrhythmicity and freezing episodes, and suggests that 30 seconds of alternating finger tapping on a portable engineered keyboard could transform the treatment of PD with telemedicine and the precision of multicenter clinical trials.
简介
在帕金森病（PD）的远程评估中，可靠且准确的僵硬度测量方法一直难以捉摸。这严重限制了远程医疗在 PD 患者护理和治疗中的应用。这也对 PD 多中心临床试验的可用结果范围以及成本产生了很大的负面影响。本研究的目的是确定工程键盘的定量测量是否敏感且与僵硬度的临床测量相关。
方法
16 名特发性 PD 患者（停用抗帕金森病药物）和 11 名年龄匹配的对照组参与者在工程键盘上执行 30 秒重复交替手指敲击任务，并使用统一帕金森病评定量表-运动部分（UPDRS-III）进行评估。
结果
与对照组相比，PD 组的按键释放速度明显较慢（p<0.0001）。在 PD 组中，按键释放速度与单侧上肢 UPDRS III 僵硬评分呈负相关（r=-0.58，p<0.0001），但与单侧上肢震颤评分无关（r=-0.14，p=0.43）。
结论
这种经过验证的僵硬度测量方法补充了我们之前对重复交替手指敲击任务的 UPDRS III、运动迟缓以及定量测量震颤、节律性和冻结事件的时间度量的验证，表明在便携式工程键盘上进行 30 秒的交替手指敲击可能会改变 PD 的治疗方式，包括远程医疗和多中心临床试验的精度。
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