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SARS-CoV-2 时代寡症状呼吸道感染患者的门诊管理:德国农村全科医生的经验。

Outpatient Management of Oligosymptomatic Patients with respiratory infection in the era of SARS-CoV-2: Experience from rural German general practitioners.

机构信息

Sauerlandpraxis Medebach-Hallenberg-Winterberg, Niederstrasse 2, 59964, Medebach, Germany.

Institute of Anatomy and Cell Biology of the Philipps-University Marburg, 35037, Marburg, Germany.

出版信息

BMC Infect Dis. 2020 Nov 6;20(1):811. doi: 10.1186/s12879-020-05538-x.

Abstract

BACKGROUND

Covid-19 is causing a pandemic and forces physicians to restructure their work. We want to share our experience in the outpatient management of potentially-infected patients with special consideration of altered national test strategies during the crisis.

METHODS

We analysed patients with respiratory symptoms reporting to our three rural general practitioner (GP) offices in North Rhine-Westphalia, Germany, from 27.01-20.04.2020 (n = 489 from a total of 6090 patients). A history of symptoms was taken at the doorstep following a specific questionnaire. Patients with respiratory symptoms were examined in a separated isolation area, while the others were allowed to enter the office. We applied the first recommended algorithm of the German Robert Koch Institute (RKI) to test suspected patients and compared our results with an adapted, more liberal version of the RKI, which is currently applied in Germany.

RESULTS

Eighty patients (16.36%, mean age: 47.03 years+ - 18.08) were sent to a nasopharyngeal smear. Five patients (6.25%) proved to be positive, four of whom had established risk factors for COVID-19. Overall, the most common symptoms were cough (83.75%), sore throat (71.25%), as well as myalgia and fatigue (66.25%). The most common diagnoses were rhinopharyngitis (37.22%) and acute bronchitis (30.27%). A sore throat was more common in positively-tested patients (80% vs. 12%). Applying the first RKI test strategy yielded 6.25% of positive tests (n = 80), while the more liberal later RKI recommendation would have achieved 1.36% positive tests from 369 patients. No positive test was missed by applying the conservative strategy. None of our employees called in sick during this period, which emphasises the efficacy and safety of our screening methods.

CONCLUSION

A clinical distinction between ordinary respiratory infections and COVID-19 is not possible in a low-prevalence population. Our model to prevent unprotected physical contact, screen patients in front of the office with protective equipment, and examine respiratory infections in separated areas works in the GP setting without overt health risks for employees. Thus, this approach should be used as a GP standard to uphold patient care without major health risks for the personnel. Large multi-centre studies are necessary to work out the most suitable test strategy.

摘要

背景

Covid-19 正在引发大流行,迫使医生们重新安排工作。我们希望分享在门诊管理中管理潜在感染患者的经验,尤其考虑到危机期间国家检测策略的变化。

方法

我们分析了自 2020 年 1 月 27 日至 4 月 20 日期间,来自德国北莱茵-威斯特法伦州三个农村全科医生办公室的出现呼吸道症状的患者(总共有 6090 名患者,其中 489 名)。我们在门口根据特定问卷采集症状史。有呼吸道症状的患者在单独的隔离区进行检查,而其他患者则允许进入办公室。我们采用德国罗伯特科赫研究所(RKI)的第一个推荐算法对疑似患者进行检测,并将我们的结果与目前在德国应用的更宽松的 RKI 改编版本进行了比较。

结果

有 80 名患者(16.36%,平均年龄:47.03 岁+/-18.08 岁)被送到鼻咽拭子处进行检测。有 5 名患者(6.25%)呈阳性,其中 4 名患者有 COVID-19 的既定危险因素。总体而言,最常见的症状是咳嗽(83.75%)、喉咙痛(71.25%)、肌肉疼痛和疲劳(66.25%)。最常见的诊断是鼻咽炎(37.22%)和急性支气管炎(30.27%)。喉咙痛在检测呈阳性的患者中更为常见(80%比 12%)。应用 RKI 的第一个检测策略,阳性检测率为 6.25%(n=80),而更宽松的 RKI 后期推荐方案则可从 369 名患者中检测出 1.36%的阳性患者。应用保守策略未漏检阳性患者。在此期间,我们没有员工请病假,这强调了我们筛查方法的有效性和安全性。

结论

在低流行地区,无法对普通呼吸道感染和 COVID-19 进行临床区分。我们在全科医生环境中预防无保护的身体接触、用防护设备在办公室前对患者进行筛查以及在单独区域检查呼吸道感染的模型没有给员工带来明显的健康风险,效果良好。因此,在不使员工面临重大健康风险的情况下,应将这种方法作为全科医生的标准,维持对患者的护理。需要开展大型多中心研究来制定最合适的检测策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a623/7648407/1fd0b89a0fb8/12879_2020_5538_Fig1_HTML.jpg

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