Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Acta Parasitol. 2021 Jun;66(2):303-328. doi: 10.1007/s11686-020-00300-4. Epub 2020 Nov 6.
Toxoplasma gondii is the global protozoa that could cause contamination in warm-blooded animals and is considered among the opportunistic pathogens in immunocompromised patients. Among the people at risk, toxoplasmosis infection can lead to the incidence of severe clinical manifestations, encephalitis, chorioretinitis, and even death.
The present research is focused on the new research for the treatment of toxoplasmosis parasitic disease using medicinal herbs.
The search was performed in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar up from 2010 to December 2019. Studies in any language were entered in the searching step if they had an English abstract. The words and terms were used as a syntax with specific tags of each database.
Out of 1832 studies, 36 were eligible to be reviewed. The findings showed that 17 studies (47%) were performed in vitro, 14 studies (39%) in vivo, and 5 studies (14%) both in vivo and in vitro.
The studies showed that the plant extracts can be a good alternative in reducing the toxoplasmosis effects in the host and the herbal extracts can be used to produce natural product-based drugs affecting toxoplasmosis with fewer side-effects than synthetic drugs.
刚地弓形虫是一种全球性的原生动物，可污染温血动物，被认为是免疫功能低下患者中的机会性病原体。在高危人群中，弓形虫感染可导致严重的临床症状、脑炎、脉络膜炎，甚至死亡。
本研究专注于使用草药治疗弓形虫寄生虫病的新研究。
从 2010 年到 2019 年 12 月，在五个英文数据库（Scopus、PubMed、Web of Science、EMBASE 和 Google Scholar）中进行了搜索。如果有英文摘要，则将任何语言的研究都纳入搜索步骤。使用特定于每个数据库的语法和术语进行搜索。
在 1832 项研究中，有 36 项符合审查标准。研究结果表明，17 项（47%）研究在体外进行，14 项（39%）在体内进行，5 项（14%）在体内和体外同时进行。
这些研究表明，植物提取物可以作为减少宿主弓形虫病影响的一种很好的替代方法，并且草药提取物可以用于生产基于天然产物的药物，与合成药物相比，副作用更少。
