Center of Excellence for Stem Cells and Regenerative Medicine (CESC), Zewail City of Science and Technology, 6th of October City, Egypt.
National Heart Institute, Giza, Egypt.
Adv Exp Med Biol. 2021;1312:51-73. doi: 10.1007/5584_2020_594.
Cardiovascular diseases top the list of fatal illnesses worldwide. Cardiac tissues is known to be one of te least proliferative in the human body, with very limited regenraive capacity. Stem cell therapy has shown great potential for treatment of cardiovascular diseases in the experimental setting, but success in human trials has been limited. Applications of stem cell therapy for cardiovascular regeneration necessitate understamding of the complex and unique structure of the heart unit, and the embryologic development of the heart muscles and vessels. This chapter aims to provide an insight into cardiac progenitor cells and their potential applications in regenerative medicine. It also provides an overview of the embryological development of cardiac tissue, and the major findings on the development of cardiac stem cells, their characterization, and differentiation, and their regenerative potential. It concludes with clinical applications in treating cardiac disease using different approaches, and concludes with areas for future research.
心血管疾病位居全球致死疾病之首。众所周知，心肌是人体中增殖能力最差的组织之一，其再生能力非常有限。在实验环境下，干细胞疗法已显示出治疗心血管疾病的巨大潜力，但在人体试验中的成功有限。干细胞疗法在心血管再生中的应用需要了解心脏单位的复杂而独特的结构，以及心脏肌肉和血管的胚胎发育。本章旨在深入了解心脏祖细胞及其在再生医学中的潜在应用。它还概述了心脏组织的胚胎发育，以及心脏干细胞的发育、特征、分化及其再生潜能的主要发现。最后介绍了使用不同方法治疗心脏疾病的临床应用，并总结了未来研究的领域。
