法医 NMR 代谢组学：又一利器。
Forensic NMR metabolomics: one more arrow in the quiver.
机构信息
Department of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.
Department of Medical Sciences and Public Health, Legal Medicine Section, University of Cagliari, Cittadella Universitaria di Monserrato, 09042, Monserrato, CA, Italy.
出版信息
Metabolomics. 2020 Nov 7;16(11):118. doi: 10.1007/s11306-020-01743-6.
INTRODUCTION
NMR metabolomics is increasingly used in forensics, due to the possibility of investigating both endogenous metabolic profiles and exogenous molecules that may help to describe metabolic patterns and their modifications associated to specific conditions of forensic interest.
OBJECTIVES
The aim of this work was to review the recent literature and depict the information provided by NMR metabolomics. Attention has been devoted to the identification of peculiar metabolic signatures and specific ante-mortem and post-mortem profiles or biomarkers related to different conditions of forensic concern, such as the identification of biological traces, the estimation of the time since death, and the exposure to drugs of abuse.
RESULTS AND CONCLUSION
The results of the described studies highlight how forensics can benefit from NMR metabolomics by gaining additional information that may help to shed light in several forensic issues that still deserve to be further elucidated.
简介
由于可以研究内源性代谢物谱和外源性分子，因此 NMR 代谢组学在法医学中得到了越来越多的应用，这些外源性分子可能有助于描述与特定法医学相关条件有关的代谢模式及其变化。
目的
本研究旨在综述近期文献并阐述 NMR 代谢组学提供的信息。研究重点关注识别特殊的代谢特征以及与法医关注的不同情况（如生物痕迹的鉴定、死亡时间的估计以及滥用药物的暴露）有关的特定死后和生前特征或生物标志物。
结果和结论
所描述研究的结果表明，法医学可以通过 NMR 代谢组学获得更多信息而受益，这些信息可能有助于阐明仍有待进一步阐明的几个法医学问题。
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