Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil; Laboratório de Neuroquímica e Psicofarmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Laboratório de Biologia Genômica e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr;242:108936. doi: 10.1016/j.cbpc.2020.108936. Epub 2020 Nov 4.
Antibiotics are widely used drugs in human and veterinary health as well as in the food industry. The majority of these compounds are, however, excreted unchanged and found as contaminants in water bodies. Although the toxicity of these drugs was previously studied in aquatic organisms, the behavioral effects of these pollutants have not been fully explored. Here we exposed adult zebrafish to environmentally relevant concentrations of different classes of antibiotics (Chlortetracycline, Ciprofloxacin, and Ceftazidime) and assessed zebrafish exploratory, cognitive, aggressive, and social behaviors. Ciprofloxacin, Chlortetracycline, and Ceftazidime exposure induced hyperlocomotion, which was characterized by an increase in the distance traveled in zebrafish. These antibiotics promoted cognitive decline and exacerbated aggressive behavior. In summary, this study shows that antibiotic contamination may impact zebrafish behavior in a short-time manner.
抗生素在人类和兽医健康以及食品工业中被广泛应用。然而，这些化合物中的大多数都未发生变化而被排泄，并作为污染物出现在水体中。尽管这些药物的毒性以前在水生生物中进行过研究，但这些污染物的行为影响尚未得到充分探索。在这里，我们将成年斑马鱼暴露于不同类别的抗生素（金霉素、环丙沙星和头孢他啶）的环境相关浓度下，并评估了斑马鱼的探索性、认知、攻击性和社交行为。环丙沙星、金霉素和头孢他啶的暴露会引起过度活跃，其特征是斑马鱼游动的距离增加。这些抗生素会导致认知能力下降并加剧攻击性行为。总之，这项研究表明，抗生素污染可能会以短期的方式影响斑马鱼的行为。
