Neural evidence of dysfunction of reward processing in women with premenstrual syndrome.

BACKGROUND

Most studies on the mechanism behind premenstrual syndrome (PMS) have focused on negative emotional overreaction, but little evidence exists regarding the weakening of positive emotions. Given the close relationship between positive emotions and reward processing, the aim of this study is to investigate the dysfunction of reward processing in women with PMS.

METHOD

Seventeen women with PMS and seventeen healthy women were scanned during a card guessing task in the late luteal phase. By selecting bilateral caudate and orbitofrontal cortex (OFC) as seed regions, region-of-interest (ROI) analysis and functional connectivity (psycho-physiological interaction [PPI]) analysis were conducted to compare the difference between two groups. Exploratory whole brain analysis was also conducted to examine the group differences in other reward-related brain regions.

RESULTS

ROI analysis revealed that healthy women showed stronger activation at the bilateral caudate and OFC when gains were contrasted to losses feedback, whereas women with PMS showed no significant difference between these two conditions. Whole brain analysis indicated that healthy women showed stronger activation at the right middle frontal gyrus (MFG) when gains were contrasted to losses feedback, whereas women with PMS showed no significant difference between these two conditions. Furthermore, separate analysis on healthy women revealed significant clusters of greater activation to gains minus losses that included the bilateral caudate, right middle temporal gyrus, and left inferior occipital gyrus; conversely, no significant clusters of activations to gains minus losses were observed in women with PMS. PPI analysis results revealed that women with PMS exhibited lower functional connectivity between the right caudate and the right cerebellum than healthy women when experiencing gains versus losses.

CONCLUSIONS

Our findings provide one of the first evidence that PMS is related to dysfunction in reward processing, which could be associated with the weakening of positive emotions.