University of Leeds.
University of Athens.
Br J Oral Maxillofac Surg. 2021 Jan;59(1):e1-e8. doi: 10.1016/j.bjoms.2020.08.084. Epub 2020 Aug 21.
Ameloblastoma is the most common benign, but locally destructive, epithelial odontogenic tumour. Peripheral ameloblastoma may involve soft tissues without invasion or involvement of bone. The aim of this structured review was to evaluate the literature and guide clinical management. Three online databases were searched for relevant studies: Medline, EMBASE, and Ovid Evidence-Based Medicine, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. A total of 520 papers were initially identified, and after exclusions were applied, 45 were included. Conservative surgical excision was the treatment of choice. There was no consensus in relation to the extent of the surgical margins required. The management of peripheral ameloblastoma appears to favour conservative excision with narrow margins of normal tissue. Follow up of at least 10 years is recommended to monitor for recurrence.
成釉细胞瘤是最常见的良性、但具有局部侵袭性的牙源性上皮肿瘤。外周成釉细胞瘤可能涉及软组织，没有侵犯或累及骨骼。本系统评价的目的是评估文献并指导临床管理。我们在三个在线数据库中搜索了相关研究：Medline、EMBASE 和 Ovid 循证医学数据库，并遵循了系统评价和荟萃分析的首选报告项目（PRISMA）指南。最初确定了 520 篇论文，应用排除标准后，纳入了 45 篇。保守性外科切除是首选的治疗方法。对于所需的手术切缘范围，目前尚无共识。外周成釉细胞瘤的治疗似乎倾向于采用保守性切除，保留正常组织的窄切缘。建议至少随访 10 年，以监测复发情况。
