Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Int J Oral Maxillofac Surg. 2021 Jun;50(6):718-724. doi: 10.1016/j.ijom.2020.09.025. Epub 2020 Nov 5.
The aim of this study was to evaluate the correlation and accuracy of depth of invasion (DOI) measurement from preoperative contrast-enhanced computed tomography (CECT) scans in comparison to histopathological examination (HPE) in oral tongue squamous cell carcinoma (OTSCC). Preoperative CT scans of 18 OTSCC patients were reviewed retrospectively by a single observer to measure the DOI on axial and coronal sections; these were then compared to the HPE report. Mean DOI was compared between CECT and HPE using repeated measures ANOVA. The strength of correlation of CT-derived tumour depth was determined using the intra-class correlation coefficient (ICC) followed by assessment of accuracy by Bland-Altman plot. In general, the measurement of DOI was smaller on CECT, with a mean difference of 0.743mm on axial CT and 1.106mm on coronal CT. Regarding the correlation between CECT and HPE tumour depths, ICC was 0.956 for axial CT and 0.965 for coronal CT. Bland-Altman analysis showed that DOI from CECT and histopathological depth were in agreement with each other. In conclusion, there was excellent correlation and accurate measurement of DOI from CECT.
本研究旨在评估术前增强计算机断层扫描（CECT）与组织病理学检查（HPE）在口腔舌鳞状细胞癌（OTSCC）中测量浸润深度（DOI）的相关性和准确性。由一位观察者回顾性地对 18 例 OTSCC 患者的术前 CT 扫描进行了评估，以在轴位和冠状位切片上测量 DOI；然后将这些与 HPE 报告进行比较。使用重复测量方差分析比较 CECT 和 HPE 之间的平均 DOI。采用组内相关系数（ICC）评估 CT 衍生肿瘤深度的相关性，然后通过 Bland-Altman 图评估准确性。一般来说，CECT 上的 DOI 测量值较小，轴向 CT 上的平均差异为 0.743mm，冠状 CT 上的平均差异为 1.106mm。关于 CECT 和 HPE 肿瘤深度之间的相关性，轴向 CT 的 ICC 为 0.956，冠状 CT 的 ICC 为 0.965。Bland-Altman 分析表明，CECT 的 DOI 与组织病理学深度具有一致性。总之，CECT 对 DOI 的测量具有极好的相关性和准确性。
