Heidl G, Davaris P, Zwadlo G, Jagoda M S, Düchting S, Bierhoff E, Grüter T, Krieg V, Sorg C
Gerhard-Domagk-Institute of Pathology, Münster, Federal Republic of Germany.
J Cancer Res Clin Oncol. 1987;113(6):567-72. doi: 10.1007/BF00390867.
Using monoclonal antibody 25 F 9, which reacts with a determinant of mature macrophages, the inflammatory infiltrate of 66 gastric carcinomas was evaluated using a counting grid. The ratio tumor cells/macrophages was determined for every tumor. For a threshold value of 5, carcinomas with a better prognosis, such as the intestinal type according to Lauré, the expanding type according to Ming and the differentiated carcinomas according to the WHO had a significantly smaller relative content of 25 F 9-positive macrophages (a minimum of P less than 0.05) than the diffuse type, infiltrative type, and undifferentiated carcinomas. Furthermore, the relative macrophage content tended to increase with the stage of carcinomas spread (P less than 0.1). The results suggested that 25 F 9-positive macrophages in gastric carcinoma are of greater significance in tumor spread than in any defensive reaction against the tumor.
使用与成熟巨噬细胞的一个决定簇发生反应的单克隆抗体25 F 9，采用计数网格对66例胃癌的炎性浸润进行评估。测定每个肿瘤的肿瘤细胞/巨噬细胞比率。对于阈值5，预后较好的癌，如劳雷分类的肠型、明分类的膨胀型以及世界卫生组织分类的分化型癌，其25 F 9阳性巨噬细胞的相对含量显著低于弥漫型、浸润型和未分化癌（最小P值小于0.05）。此外，巨噬细胞相对含量倾向于随癌扩散阶段增加（P值小于0.1）。结果表明，胃癌中25 F 9阳性巨噬细胞在肿瘤扩散方面比在任何抗肿瘤防御反应中具有更大的意义。
