Bukkitgar Shikandar D, Shetti Nagaraj P, Aminabhavi Tejraj M
Centre for Electrochemical Science and Materials, Department of Chemistry, K.L.E. Institute of Technology, Gokul, Hubballi 580030, Karnataka, India.
Pharmaceutical Engineering, Soniya College of Pharmacy, Dharwad 580-007, India.
Chem Eng J. 2021 Sep 15;420:127575. doi: 10.1016/j.cej.2020.127575. Epub 2020 Nov 2.
Virus-induced infection such as SARS-CoV-2 is a serious threat to human health and the economic setback of the world. Continued advances in the development of technologies are required before the viruses undergo mutation. The low concentration of viruses in environmental samples makes the detection extremely challenging; simple, accurate and rapid detection methods are in urgent need. Of all the analytical techniques, electrochemical methods have the established capabilities to address the issues. Particularly, the integration of nanotechnology would allow miniature devices to be made available at the point-of-care. This review outlines the capabilities of electrochemical methods in conjunction with nanotechnology for the detection of SARS-CoV-2. Future directions and challenges of the electrochemical biosensors for pathogen detection are covered including wearable and conformal biosensors, detection of plant pathogens, multiplexed detection, and reusable biosensors for on-site monitoring, thereby providing low-cost and disposable biosensors.
诸如严重急性呼吸综合征冠状病毒2（SARS-CoV-2）之类的病毒引起的感染对人类健康和世界经济衰退构成严重威胁。在病毒发生突变之前，需要技术开发持续取得进展。环境样本中病毒浓度低使得检测极具挑战性；迫切需要简单、准确和快速的检测方法。在所有分析技术中，电化学方法有能力解决这些问题。特别是，纳米技术的整合将使即时检测的微型设备成为可能。本综述概述了结合纳米技术的电化学方法检测SARS-CoV-2的能力。涵盖了用于病原体检测的电化学生物传感器的未来方向和挑战，包括可穿戴和贴合式生物传感器、植物病原体检测、多重检测以及用于现场监测的可重复使用生物传感器，从而提供低成本和一次性生物传感器。
