Bill & Melinda Gates Medical Research Institute, Cambridge, MA, United States.
Front Immunol. 2020 Oct 14;11:517290. doi: 10.3389/fimmu.2020.517290. eCollection 2020.
Six of the top ten leading causes of death in low resource settings could potentially be prevented by vaccination. Development of vaccines for individuals in these populations is difficult because of the biological complexity of the prevalent pathogens and the challenges inherent to development of any vaccine. This review discusses those challenges and promising advances to address them and highlights recent progress in development of vaccines against several pathogens of interest.
在资源匮乏的环境中，十大主要死因中有六种可以通过接种疫苗来预防。由于流行病原体的生物学复杂性以及任何疫苗开发固有的挑战，为这些人群中的个体开发疫苗具有挑战性。本文讨论了这些挑战以及有希望克服这些挑战的进展，并重点介绍了针对几种相关病原体的疫苗开发的最新进展。
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