William Harvey Research Institute, Centre for Advanced Cardiovascular Imaging, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Barts Heart Centre, Department of Cardiac Imaging, St. Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.
Eur Heart J Cardiovasc Imaging. 2021 Feb 22;22(3):251-258. doi: 10.1093/ehjci/jeaa297.
The UK Biobank (UKB) is a health research resource of major international importance, incorporating comprehensive characterization of >500 000 men and women recruited between 2006 and 2010 from across the UK. There is prospective tracking of health outcomes for all participants through linkages with national cohorts (death registers, cancer registers, electronic hospital records, and primary care records). The dataset has been enhanced with the UKB imaging study, which aims to scan a subset of 100 000 participants. The imaging protocol includes magnetic resonance imaging of the brain, heart, and abdomen, carotid ultrasound, and whole-body dual X-ray absorptiometry. Since its launch in 2015, over 48 000 participants have completed the imaging study with scheduled completion in 2023. Repeat imaging of 10 000 participants has been approved and commenced in 2019. The cardiovascular magnetic resonance (CMR) scan provides detailed assessment of cardiac structure and function comprising bright blood anatomic assessment (sagittal, coronal, and axial), left and right ventricular cine images (long and short axes), myocardial tagging, native T1 mapping, aortic flow, and imaging of the thoracic aorta. The UKB is an open access resource available to health researchers across all scientific disciplines from both academia and industry with no preferential access or exclusivity. In this paper, we consider how we may best utilize the UKB CMR data to advance cardiovascular research and review notable achievements to date.
英国生物银行（UKB）是一个具有重大国际意义的健康研究资源，整合了 2006 年至 2010 年间从英国各地招募的超过 50 万男性和女性的综合特征描述。所有参与者的健康结果都通过与国家队列（死亡登记、癌症登记、电子医院记录和初级保健记录）的链接进行前瞻性跟踪。该数据集通过 UKB 成像研究得到了增强，该研究旨在对 10 万名参与者中的一部分进行扫描。成像协议包括大脑、心脏和腹部的磁共振成像、颈动脉超声和全身双能 X 射线吸收测定法。自 2015 年启动以来，已有超过 48000 名参与者完成了成像研究，预计在 2023 年完成。已批准并于 2019 年开始对 10000 名参与者进行重复成像。心血管磁共振（CMR）扫描提供了心脏结构和功能的详细评估，包括亮血解剖评估（矢状面、冠状面和轴面）、左心室和右心室电影图像（长轴和短轴）、心肌标记、固有 T1 映射、主动脉流量和胸主动脉成像。UKB 是一个开放获取资源，可供学术界和工业界所有科学学科的健康研究人员使用，没有优先访问或排他性。在本文中，我们考虑如何最好地利用 UKB CMR 数据来推进心血管研究，并回顾迄今为止的显著成就。
