从卡纳塔克邦迈索尔一家三级护理医院的艾滋病患者中分离出的菌种的抗真菌耐药性
Antifungal Resistance of Species Isolated from HIV Patients in a Tertiary Care Hospital, Mysuru, Karnataka.
作者信息
Shivaswamy Umamaheshwari, Sumana M N
机构信息
Division of Microbiology, Department of Water and Health, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
Department of Microbiology, JSS Medical College and Hospital, Mysuru, Karnataka, India.
出版信息
Indian J Dermatol. 2020 Sep-Oct;65(5):423-425. doi: 10.4103/ijd.IJD_385_19.
CONTEXT
Candidiasis still remains as a common opportunistic infection in patients with human immunodeficiency virus (HIV). Drug resistance has become a serious health concern because of indiscriminate usage and dosage.
AIM
To determine the antifungal resistance pattern of and non-albicans Candida (NAC) from HIV patients.
SUBJECTS AND METHODS
The study was carried out in the department of microbiology at a tertiary care hospital. Candida isolates obtained from HIV patients were tested for drug susceptibility by Vitek-2 automated system.
RESULTS
Antifungal susceptibility pattern (n=109) revealed that 15% of the isolates were resistant to at-least one and 85% were sensitive to all the drugs tested. About 10% and 19% of showed resistance to fluconazole and flucytosine respectively. Among non-albicans tested, only (14%) exhibited resistance to flucytosine.
CONCLUSIONS
Knowledge on epidemiology, species prevalence, and drug resistance pattern may guide for effective therapy. This reduces morbidity and also improves the quality of life.
背景
念珠菌病在人类免疫缺陷病毒（HIV）感染者中仍然是一种常见的机会性感染。由于药物的滥用和不当剂量，耐药性已成为一个严重的健康问题。
目的
确定HIV患者中白色念珠菌和非白色念珠菌（NAC）的抗真菌耐药模式。
对象与方法
本研究在一家三级医疗机构的微生物科进行。从HIV患者中分离出的念珠菌菌株通过Vitek-2自动化系统进行药敏试验。
结果
抗真菌药敏模式（n=109）显示，15%的分离株对至少一种药物耐药，85%对所有测试药物敏感。约10%的白色念珠菌对氟康唑耐药，19%对氟胞嘧啶耐药。在测试的非白色念珠菌中，只有热带念珠菌（14%）对氟胞嘧啶耐药。
结论
了解流行病学、菌种流行情况和耐药模式可为有效治疗提供指导。这可降低发病率并提高生活质量。
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