Department of Neurology.
Lawrence Berkeley National Laboratory.
Psychol Aging. 2020 Nov;35(7):993-999. doi: 10.1037/pag0000582.
Little is known about the association between personality and Alzheimer's disease (AD) biomarkers, and existing results are inconsistent. We aimed to determine whether personality was associated with β-amyloid (Aβ) accumulation in cognitively normal aging. One hundred twenty-nine participants were included in this cross-sectional study. Personality was measured with the Big Five Inventory (BFI) and brain Aβ deposition was assessed with [11C] Pittsburgh compound B (PiB)-positron emission tomography (PET) imaging. Conscientiousness scores had a negative association with global PiB distribution volume ratio (DVR) in all participants after adjusting for age, sex, education, and vascular risk factors (β[SE] = -0.19[0.09], 95% confidence interval [CI: -0.35, -0.02], p = .031), while agreeableness, extraversion, neuroticism, and openness had no association with global PiB DVR. Assuming the relative stability of personality traits, these findings suggest that conscientiousness may protect against Aβ accumulation in cognitively normal aging through mechanisms that are as yet unknown. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
目前人们对于个性与阿尔茨海默病（AD）生物标志物之间的关系知之甚少，且现有结果并不一致。我们旨在确定个性是否与认知正常老化过程中的β-淀粉样蛋白（Aβ）积累有关。本横断面研究共纳入 129 名参与者。使用大五人格量表（BFI）测量个性，并用[11C]匹兹堡化合物 B（PiB）-正电子发射断层扫描（PET）成像评估脑 Aβ沉积。在调整年龄、性别、教育和血管危险因素后，所有参与者的尽责性评分与全局 PiB 分布容积比（DVR）呈负相关（β[SE] = -0.19[0.09]，95%置信区间 [CI：-0.35，-0.02]，p =.031），而宜人性、外向性、神经质和开放性与全局 PiB DVR 无关联。假设个性特征具有相对稳定性，这些发现表明尽责性可能通过尚未明确的机制来预防认知正常老化过程中的 Aβ积累。（PsycInfo 数据库记录（c）2020 APA，保留所有权利）。
