脂肪组织中的嗜酸性粒细胞会火上浇油吗？
Can eosinophils in adipose tissue add fuel to the fire?
作者信息
Jacobsen Elizabeth A, De Filippis Eleanna
机构信息
Division of Allergy and Immunology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Division of Endocrinology and Metabolism, Mayo Clinic Arizona, Scottsdale, AZ, USA.
出版信息
Immunol Cell Biol. 2021 Jan;99(1):13-16. doi: 10.1111/imcb.12407. Epub 2020 Nov 9.
Abstract
In inguinal adipose tissue, beige adipocytes are interspersed among white adipocytes and in close communication with dynamic populations of immune cells. Recent data have demonstrated that anti-inflammatory macrophages (M2) increase thermogenic activity of beige adipocytes, although the mechanism is currently under debate. ILC2, cells via secretion, of methionine enkephalin peptide were found to be able to increase beige thermogenesis. Knights et al. have recently generated a whole-body knock-out of KLF3 (KLF3-/-) to explore its contribution to thermogenesis and weight gain in a diet-induced obesity animal model.
摘要
在腹股沟脂肪组织中，米色脂肪细胞散布于白色脂肪细胞之间，并与动态的免疫细胞群体密切交流。最近的数据表明，抗炎巨噬细胞（M2）可增加米色脂肪细胞的产热活性，尽管其机制目前仍存在争议。研究发现，2型固有淋巴细胞（ILC2）通过分泌甲硫氨酸脑啡肽能够增加米色脂肪产热。奈茨等人最近构建了KLF3基因全身敲除小鼠（KLF3-/-），以探究其在饮食诱导的肥胖动物模型中对产热和体重增加的作用。
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