ZBTB7A 在结直肠癌中发挥癌基因作用。
ZBTB7A functioned as an oncogene in colorectal cancer.
机构信息
Department of Radiotherapy, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200000, China.
Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, China.
出版信息
BMC Gastroenterol. 2020 Nov 9;20(1):370. doi: 10.1186/s12876-020-01456-z.
BACKGROUND
Despite zinc finger and BTB domain-containing 7A (ZBTB7A) documented importance in multiple tumors, the function and clinical value in Colorectal cancer (CRC) remain elusive. The aim of this study was to evaluate the functional roles and the clinical value of ZBTB7A in CRC progression.
METHODS
The level of ZBTB7A was detected in a large cohort of CRC patients (n = 189) by immunohistochemistry (IHC), and we analyzed the diagnostic and prognostic value of the protein. In addition, the functional roles of ZBTB7A on CRC were explored in vitro and in vivo.
RESULTS
Survival analyses indicated that patients with high ZBTB7A expression made the prognosis worse (P = 0.024). Functionally, knockdown of ZBTB7A could markedly inhibit tumor proliferation in vitro and in vivo, whereas ZBTB7A overexpression displayed the opposite results.
CONCLUSIONS
ZBTB7A was associated with poor survival outcomes and functioned as an oncogene in CRC patients, indicating that it is a potential prognostic biomarker and therapeutic target for CRC patients.
背景
尽管锌指和 BTB 结构域蛋白 7A（ZBTB7A）在多种肿瘤中具有重要作用，但它在结直肠癌（CRC）中的功能和临床价值仍不清楚。本研究旨在评估 ZBTB7A 在 CRC 进展中的功能作用和临床价值。
方法
通过免疫组织化学（IHC）检测了大量 CRC 患者（n=189）中 ZBTB7A 的水平，并分析了该蛋白的诊断和预后价值。此外，还在体外和体内探索了 ZBTB7A 对 CRC 的功能作用。
结果
生存分析表明，高 ZBTB7A 表达的患者预后更差（P=0.024）。功能上，ZBTB7A 敲低可显著抑制体外和体内的肿瘤增殖，而 ZBTB7A 过表达则显示出相反的结果。
结论
ZBTB7A 与不良生存结局相关，并在 CRC 患者中发挥癌基因的作用，表明它是 CRC 患者潜在的预后生物标志物和治疗靶点。
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