Singh Atul Kumar, Verma Shiv, Kushwaha Prem Prakash, Prajapati Kumari Sunita, Shuaib Mohd, Kumar Shashank, Gupta Sanjay
Molecular Signaling and Drug Discovery Laboratory, Department of Biochemistry, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151401, India.
Department of Urology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Mol Biol Rep. 2021 May;48(5):4703-4719. doi: 10.1007/s11033-021-06405-x. Epub 2021 May 20.
The zinc finger and BTB (broad-complex, tramtrack and bric a brac) domain containing protein 7A (ZBTB7A) is a pleiotropic transcription factor that plays an important role in various stages of cell proliferation, differentiation, and other developmental processes. ZBTB7A is a member of the POK family that directly and specifically binds to short DNA recognition sites located near their target genes thereby acting as transcriptional activator or repressor. ZBTB7A overexpression has been associated with tumorigenesis and metastasis in various human cancer types, including breast, prostate, lung, ovarian, and colon cancer. However in some instances downregulation of ZBTB7A results in tumor progression, suggesting its role as a tumor suppressor. ZBTB7A is involved with complicated regulatory networks which include protein-protein and protein-nucleic acid interactions. ZBTB7A involvement in cancer progression and metastasis is perhaps enabled through the regulation of various signaling pathways depending on the type and genetic context of cancer. The association of ZBTB7A with other proteins affects cancer aggressiveness, therapeutic resistance and clinical outcome. This review focuses on the involvement of ZBTB7A in various signaling pathways and its role in cancer progression. We will also review the literature on ZBTB7A and cancer which could be potentially explored for its therapeutic implications.
含锌指和BTB（broad-complex、tramtrack和bric a brac）结构域蛋白7A（ZBTB7A）是一种多效性转录因子，在细胞增殖、分化及其他发育过程的各个阶段发挥重要作用。ZBTB7A是POK家族成员，可直接且特异性地结合位于其靶基因附近的短DNA识别位点，从而作为转录激活因子或抑制因子发挥作用。ZBTB7A的过表达与多种人类癌症类型（包括乳腺癌、前列腺癌、肺癌、卵巢癌和结肠癌）的肿瘤发生和转移相关。然而，在某些情况下，ZBTB7A的下调会导致肿瘤进展，提示其作为肿瘤抑制因子的作用。ZBTB7A参与复杂的调控网络，包括蛋白质-蛋白质和蛋白质-核酸相互作用。ZBTB7A参与癌症进展和转移可能是通过根据癌症类型和基因背景调控各种信号通路实现的。ZBTB7A与其他蛋白质的关联会影响癌症的侵袭性、治疗耐药性和临床结局。本综述重点关注ZBTB7A在各种信号通路中的作用及其在癌症进展中的角色。我们还将综述关于ZBTB7A与癌症的文献，其可能具有潜在的治疗意义可供探索。
