原发性震颤与震颤为主型帕金森病患者的嗅觉功能障碍。

Olfactory dysfunction in essential tremor versus tremor dominant Parkinson disease.

机构信息

Faculty of Medicine, Tanta University, Egypt.

Tanta University, Egypt.

出版信息

Clin Neurol Neurosurg. 2021 Jan;200:106352. doi: 10.1016/j.clineuro.2020.106352. Epub 2020 Nov 2.

DOI:10.1016/j.clineuro.2020.106352

PMID:33168334

Abstract

BACKGROUND

Essential tremor (ET) and tremor dominant Parkinson disease (TDPD) variant constitute the main causes of geriatric tremor which differentiation is not always an easy mission. The objective of this work was to study the olfactory performance in ET and PD patients for possible consideration as a differentiating biomarker.

METHODS

This study was performed on 36ET, 22 TDPD variant and 24 healthy controls subjects (HCS) submitted to extended n-butanol Sniffin' Sticks test (SST) and olfactory bulbs volumetry (OBV).

RESULTS

There were significant decreases in SST threshold, discrimination, identification and TDI variables in TDPD patients compared to ET and HCS. ET patients showed significant decrease in the same variables compared to HCS. Regarding OBV, there were significant decreases in TDPD patients compared to ET and HCS with nonsignificant difference between the 2-latter groups. Our results showed that TDI score of 25 can differentiate between TDPD and ET patients with sensitivity and specificity (94 %, 91 %) respectively.

CONCLUSION

Olfactory assessment is a rapid, safe, and easily applicable biomarker that could differentiate TDPD from ET in doubtful cases.

摘要

背景

特发性震颤（ET）和震颤为主的帕金森病（TDPD）变异型是导致老年震颤的主要原因，而区分这两者并不总是一件容易的事。本研究旨在研究 ET 和 PD 患者的嗅觉表现，以期将其作为一种有区别的生物标志物。

方法

本研究纳入了 36 名 ET 患者、22 名 TDPD 变异型患者和 24 名健康对照者（HCS），对其进行了扩展的 n-丁醇嗅探测试（SST）和嗅球容积（OBV）检查。

结果

与 ET 和 HCS 相比，TDPD 患者的 SST 阈值、辨别力、识别力和 TDI 变量显著降低。与 HCS 相比，ET 患者在相同变量上也有显著下降。在 OBV 方面，与 ET 和 HCS 相比，TDPD 患者明显下降，而后两组之间无显著差异。我们的结果表明，TDI 评分 25 可以区分 TDPD 和 ET 患者，其敏感性和特异性分别为 94%和 91%。