Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Nat Neurosci. 2020 Dec;23(12):1550-1554. doi: 10.1038/s41593-020-00732-1. Epub 2020 Nov 9.
The brain generates negative prediction error (NPE) signals to trigger extinction, a type of inhibitory learning that is responsible for suppressing learned behaviors when they are no longer useful. Neurons encoding NPE have been reported in multiple brain regions. Here, we use an optogenetic approach to demonstrate that GABAergic cerebello-olivary neurons can generate a powerful NPE signal, capable of causing extinction of conditioned motor responses on its own.
大脑会产生负预测误差 (NPE) 信号来触发消除，这是一种抑制性学习，当习得的行为不再有用时，它负责抑制这些行为。已有研究报道，多个脑区的神经元可编码 NPE。在这里，我们使用光遗传学方法证明 GABA 能性小脑橄榄神经元可以产生强大的 NPE 信号，能够独立引起条件运动反应的消除。
