Department of Experimental Medical Science, Lund University, Lund, Sweden.
Unit of Neuropsychiatry, Hospital of Helsingborg, Helsingborg, Sweden.
Cerebellum. 2024 Oct;23(5):1859-1866. doi: 10.1007/s12311-024-01682-1. Epub 2024 Mar 11.
Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber responses through in-vivo intracellular Purkinje cell recordings in decerebrated ferrets. The results show that while nucleo-olivary stimulation decreased the probability of a response occurring at all, it did not reduce the number of EPSPs. The results suggest that nucleo-olivary stimulation does not influence the number of EPSPs in climbing fiber bursts.
climbing fibers，连接下橄榄核和浦肯野细胞，形成神经系统最强的神经连接。这些纤维在关键事件后激活，如运动错误或预期的奖励，导致浦肯野细胞中爆发兴奋性突触后电位 (EPSPs)。当大脑学习新的运动技能时，EPSPs 的数量是一个关键变量。然而，我们不知道是什么决定了 EPSPs 的数量。在这里，我们通过对去大脑化雪貂的浦肯野细胞进行活体细胞内记录，测量了核橄榄刺激对眶周诱发的 climbing fiber 反应的影响。结果表明，虽然核橄榄刺激降低了所有反应发生的概率，但它并没有减少 EPSPs 的数量。结果表明，核橄榄刺激不影响 climbing fiber 爆发中的 EPSPs 数量。
