Kim J J, Krupa D J, Thompson R F
Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA.
Science. 1998 Jan 23;279(5350):570-3. doi: 10.1126/science.279.5350.570.
The behavioral phenomenon of blocking indicates that the informational relationship between the conditioned stimulus and the unconditioned stimulus is essential in classical conditioning. The eyeblink conditioning paradigm is used to describe a neural mechanism that mediates blocking. Disrupting inhibition of the inferior olive, a structure that conveys unconditioned stimulus information (airpuff) to the cerebellum prevented blocking in rabbits. Recordings of cerebellar neuronal activity show that the inferior olive input to the cerebellum becomes suppressed as learning occurs. These results suggest that the inferior olive becomes functionally inhibited by the cerebellum during conditioning, and that this negative feedback process might be the neural mechanism mediating blocking.
阻断这一行为现象表明，条件刺激与非条件刺激之间的信息关系在经典条件反射中至关重要。眨眼条件反射范式被用于描述介导阻断的神经机制。破坏下橄榄核的抑制作用（下橄榄核是一种将非条件刺激信息（吹气）传递至小脑的结构）可防止兔子出现阻断现象。小脑神经元活动记录显示，随着学习的发生，从小脑传入的下橄榄核输入受到抑制。这些结果表明，在条件反射过程中下橄榄核在功能上受到小脑的抑制，并且这种负反馈过程可能是介导阻断的神经机制。
