Heart and Sole Africa, Musanze, Musanze District, PO Box 30, Rwanda.
Centre for One Health, University of Global Health Equity, Kigali, PO Box 6955, Rwanda.
Trans R Soc Trop Med Hyg. 2020 Dec 16;114(12):947-953. doi: 10.1093/trstmh/traa068.
Podoconiosis is a progressive swelling of the legs affecting genetically susceptible people who live in areas with irritant red clay soils and walk barefoot. The disease is a public health concern in many countries, including Rwanda.
This retrospective study described individual and familial characteristics of patients with podoconiosis attending the Heart and Sole Africa (HASA) clinics in Rwanda. Data on patient characteristics and family history were retrieved from electronic medical records (January 2013 - August 2019). A multiple regression analysis was used to explore factors influencing age of onset of podoconiosis.
Among 467 patients with podoconiosis, the mean (standard deviation) age of onset was 34.4 (19.6) years, 139 (29.8%) patients developed podoconiosis at <20 years of age, 417 (89%) came from Musanze or neighboring Burera Districts, and 238 (51.0%) had a family history of podoconiosis. Increasing patient age was associated with older age at onset of disease (p<0.001), while an increased number of relatives with podoconiosis (p<0.002) was significantly associated with earlier disease onset.
Most patients with podoconiosis were women, and more than half had a family history of podoconiosis. An increased number of relatives with podoconiosis was associated with a significantly younger age at disease onset.
Podoconiosis 是一种腿部进行性肿胀的疾病，影响生活在有刺激性红土且赤脚行走的遗传易感人群。该病是许多国家（包括卢旺达）的公共卫生关注点。
本回顾性研究描述了在卢旺达 Heart and Sole Africa（HASA）诊所就诊的 Podoconiosis 患者的个体和家族特征。从电子病历中检索患者特征和家族史数据（2013 年 1 月至 2019 年 8 月）。采用多元回归分析探讨影响 Podoconiosis 发病年龄的因素。
在 467 名 Podoconiosis 患者中，发病年龄的平均值（标准差）为 34.4（19.6）岁，139 名（29.8%）患者在<20 岁时发病，417 名（89%）来自 Musanze 或邻近的 Burera 区，238 名（51.0%）有 Podoconiosis 家族史。患者年龄增加与发病年龄增加相关（p<0.001），而家族中患有 Podoconiosis 的亲属数量增加（p<0.002）与疾病发病年龄提前显著相关。
大多数 Podoconiosis 患者为女性，超过一半有 Podoconiosis 家族史。家族中患有 Podoconiosis 的亲属数量增加与发病年龄显著提前相关。
