血清脯氨酸酶、丙二醛和过氧化氢酶水平评估外周性眩晕患者的氧化应激。
Serum prolidase, malondialdehyde and catalase levels for the evaluation of oxidative stress in patients with peripheral vertigo.
机构信息
Department of Otolaryngology, Atasehir Avicenna Hospital, Istanbul, Turkey.
Department of Otolaryngology, Kutahya Saglık Bilimleri University, Kutahya, Turkey.
出版信息
Eur Arch Otorhinolaryngol. 2021 Oct;278(10):3773-3776. doi: 10.1007/s00405-020-06466-x. Epub 2020 Nov 9.
PURPOSE
We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring serum prolidase, malondialdehyde (MDA) and catalase levels.
METHODS
A total of 30 patients (age: 60 <) with peripheral vertigo and 30 healthy subjects were recruited. Blood samples were collected from both groups and serum prolidase levels were measured using enzyme-linked immunosorbent assay (ELISA). MDA and catalase levels were measured by the spectrophotometric method.
RESULTS
The most common cause of vertigo was BPPV (53.3%), followed by Ménière's disease (16.6%), vestibular neuritis (13.3%), lateral semicircular canal fistula (3.3%), and idiopathic vertigo (13.3%). Mean serum prolidase activity and MDA levels were significantly higher in the vertigo patients than in the control subjects (P < 0.05); however, there was no statistically significant difference in mean serum catalase levels between the groups (P > 0.05).
CONCLUSION
We concluded that serum prolidase and MDA levels may be used as markers of oxidative stress in patients with peripheral vertigo.
目的
通过测量血清脯氨酸酶、丙二醛（MDA）和过氧化氢酶水平，评估外周性眩晕患者的氧化应激。
方法
共纳入 30 例外周性眩晕患者（年龄：60<）和 30 例健康对照者。采集两组血样，采用酶联免疫吸附试验（ELISA）测定血清脯氨酸酶水平。采用分光光度法测定 MDA 和过氧化氢酶水平。
结果
眩晕最常见的病因是良性阵发性位置性眩晕（BPPV，53.3%），其次是梅尼埃病（Ménière 病，16.6%）、前庭神经炎（vestibular neuritis，13.3%）、外半规管瘘（lateral semicircular canal fistula，3.3%）和特发性眩晕（idiopathic vertigo，13.3%）。与对照组相比，眩晕患者的血清脯氨酸酶活性和 MDA 水平显著升高（P<0.05）；但两组间血清过氧化氢酶水平无统计学差异（P>0.05）。
结论
我们得出结论，血清脯氨酸酶和 MDA 水平可作为外周性眩晕患者氧化应激的标志物。
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