Klevay L M
United States Department of Agriculture, Human Nutrition Research Center, Grand Forks, North Dakota 58202.
Med Hypotheses. 1987 Oct;24(2):111-9. doi: 10.1016/0306-9877(87)90093-4.
A new hypothesis suggests that deficiency of copper is important in the etiology and pathophysiology of ischemic heart disease. Several chemicals, called cholesterotropic and cuprotropic, that affect cholesterolemia also affect copper metabolism. Responses to some of these chemicals that have been tested in humans were compared on a molar basis. Dietary copper was approximately one hundred times as active in lowering cholesterol in plasma than was clofibrate which, in turn was six times as active as dietary fat. Dietary copper may be a powerful determinent of cholesterolemia.
一种新的假说认为，铜缺乏在缺血性心脏病的病因学和病理生理学中具有重要意义。几种被称为促胆固醇和促铜的化学物质，它们影响胆固醇血症的同时也影响铜代谢。在摩尔基础上比较了人类对其中一些已测试化学物质的反应。膳食铜降低血浆胆固醇的活性约为氯贝丁酯的一百倍，而氯贝丁酯降低血浆胆固醇的活性又是膳食脂肪的六倍。膳食铜可能是胆固醇血症的一个重要决定因素。
