Klevay L M, Viestenz K E
Am J Physiol. 1981 Feb;240(2):H185-9. doi: 10.1152/ajpheart.1981.240.2.H185.
According to a new hypothesis based on epidemiologic observations, iatrogenic maneuvers, natural occurrences, and animal experiments, absolute or relative deficiency of copper is of prime importance in the etiology of ischemic heart disease. Male weanling rats were made copper deficient with a purified diet containing 0.79 microgram Cu/g diet and containing all other nutrients known to be essential. Deficiency was verified by a 39% increase in cholesterolemia. Electrocardiograms of copper-deficient rats showed several abnormalities including S-T segment depression for one-third to one-half of the R-R interval, bundle branch block with R waves three times normal height and width, Q waves, and second- and third-degree heart block. Copper deficiency shortened the lives of the rats by 73%. Copper deficiency is the only nutritional insult that has produced rapid unfavorable alterations in lipid metabolism, cardiac and arterial anatomy, and cardiac electrophysiology. Copper metabolism may be important in the etiology of ischemic heart disease and in the arrhythmias associated with the consumption of liquid-protein diets.
基于流行病学观察、医源性操作、自然现象及动物实验提出的一项新假说表明，铜的绝对或相对缺乏在缺血性心脏病的病因中至关重要。给雄性断乳大鼠喂食一种纯化日粮，使其缺铜，该日粮含0.79微克铜/克日粮，且含有所有已知的必需营养素。通过胆固醇血症升高39%证实了铜缺乏。缺铜大鼠的心电图显示出几种异常，包括R-R间期的三分之一至二分之一出现S-T段压低、束支传导阻滞（R波高度和宽度为正常的三倍）、Q波以及二度和三度心脏传导阻滞。铜缺乏使大鼠寿命缩短了73%。铜缺乏是唯一一种对脂质代谢、心脏和动脉解剖结构以及心脏电生理产生快速不利改变的营养损害。铜代谢可能在缺血性心脏病的病因以及与食用流质蛋白饮食相关的心律失常中起重要作用。
