Vlad M, Bordas E, Caseanu E, Uza G, Creteanu E, Polinicenco C
Institute of Public Health and Medical Research, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Biol Trace Elem Res. 1995 Apr;48(1):99-109. doi: 10.1007/BF02789082.
The effect of Cuprofilin, a newly synthesized C.(II)-chlorophyll complex, was assessed in rats with experimental atherosclerosis. The study was focused on changes in serum cholesterol, lipids, and triglycerides concentration as well as on serum and abdominal aorta Cu and Zn values. It has been ascertained that after 90 d in animals fed a rich lipid diet there was a statistically significant increase in serum cholesterol, triglycerides, and lipid concentration (p < 0.01). A significant augmentation of serum Cu values (p < 0.01) accompanied by a marked lowering of the same element in abdominal aorta (p < 0.01) was also found, as compared to the results registered in the control group. However, Cuprofilin, administered for 90 d in the group of animals with experimental atherosclerosis, significantly decreased the serum cholesterol, triglycerides, and serum lipid values (p < 0.01), increased copper content in aortic tissue (p < 0.01) and lowered serum copper concentration (p < 0.01) as compared to the untreated group. Moreover, in the aorta of administered animals the lipid infiltration has been demonstrated to be significantly diminished vs the untreated group.
对一种新合成的铜叶绿素复合物Cuprofilin在实验性动脉粥样硬化大鼠中的作用进行了评估。该研究聚焦于血清胆固醇、脂质和甘油三酯浓度的变化，以及血清和腹主动脉中铜和锌的值。已确定，在喂食富含脂质饮食的动物中，90天后血清胆固醇、甘油三酯和脂质浓度有统计学显著升高（p < 0.01）。与对照组的结果相比，还发现血清铜值显著升高（p < 0.01），同时腹主动脉中同一元素显著降低（p < 0.01）。然而，在患有实验性动脉粥样硬化的动物组中给予Cuprofilin 90天，与未治疗组相比，血清胆固醇、甘油三酯和血清脂质值显著降低（p < 0.01），主动脉组织中的铜含量增加（p < 0.01），血清铜浓度降低（p < 0.01）。此外，与未治疗组相比，在给药动物的主动脉中，脂质浸润已被证明显著减少。
